Sandbox 78: Difference between revisions
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== Function == | == Function == | ||
HGL, similarly to other members of the human lipase superfamily, are all serine esterases and have similar tertiary structure, evident by the conserved disulfide bonds. However, HGL is much more pH stable, allowing this pre-duodenal lipase to be active in the stomach (pH 1.7)'''*** CITE http://www.ncbi.nlm.nih.gov/pubmed/2395805''' and continue to be active as chyme moves into the duodenum (pH 6.1)'''*** CITE http://www.ncbi.nlm.nih.gov/pubmed/2395805'''. | HGL, similarly to other members of the human lipase superfamily, are all serine esterases and have similar tertiary structure, evident by the conserved disulfide bonds. However, HGL is much more pH stable, allowing this pre-duodenal lipase to be active in the stomach (pH 1.7)'''*** CITE http://www.ncbi.nlm.nih.gov/pubmed/2395805''' and continue to be active as chyme moves into the duodenum (pH 6.1)'''*** CITE http://www.ncbi.nlm.nih.gov/pubmed/2395805'''. As the | ||
== Relevance to Human Health & Disease == | == Relevance to Human Health & Disease == | ||