2bwk: Difference between revisions
New page: left|200px<br /> <applet load="2bwk" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bwk, resolution 1.50Å" /> '''MURINE ANGIOGENIN, ... |
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==About this Structure== | ==About this Structure== | ||
2BWK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BWK OCA]]. | 2BWK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BWK OCA]]. | ||
==Reference== | ==Reference== | ||
Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies., Holloway DE, Chavali GB, Hares MC, Subramanian V, Acharya KR, Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1568-78. Epub 2005, Nov 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16301790 16301790] | Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies., Holloway DE, Chavali GB, Hares MC, Subramanian V, Acharya KR, Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1568-78. Epub 2005, Nov 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16301790 16301790] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Pancreatic ribonuclease]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Acharya, K.R.]] | [[Category: Acharya, K.R.]] | ||
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[[Category: ribonuclease]] | [[Category: ribonuclease]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:04:02 2007'' | ||
Revision as of 11:59, 30 October 2007
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MURINE ANGIOGENIN, SULPHATE COMPLEX
OverviewOverview
Angiogenin is an unusual member of the pancreatic ribonuclease superfamily, that induces blood-vessel formation and is a promising anticancer target., The three-dimensional structure of murine angiogenin (mAng) has been, determined by X-ray crystallography. Two structures are presented: one is, a complex with sulfate ions (1.5 Angstroms resolution) and the other a, complex with phosphate ions (1.6 Angstroms resolution). Residues forming, the putative B(1), P(1) and B(2) subsites occupy positions similar to, their hAng counterparts and are likely to play similar roles. The anions, occupy the P(1) subsite, sulfate binding conventionally and phosphate, adopting two orientations, one of which is novel. The B(1) subsite is, obstructed by Glu116 and Phe119, with the latter assuming a less ... [(full description)]
About this StructureAbout this Structure
2BWK is a [Single protein] structure of sequence from [Mus musculus] with SO4 as [ligand]. Active as [Pancreatic ribonuclease], with EC number [3.1.27.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies., Holloway DE, Chavali GB, Hares MC, Subramanian V, Acharya KR, Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1568-78. Epub 2005, Nov 19. PMID:16301790
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