Jumonji domain-containing protein: Difference between revisions
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== Function == | == Function == | ||
'''Jumonji domain-containing protein 2a''' (Jmjd2a) or '''KDM4A''' catalyzes the demethylation of trimethylated histone H3 at lysine residues 9 and 36 producing the dimethylated form. Jmjd2a domains contain: N-terminal, catalytic core (residues 1-350), 2 TUDOR domains which recognize dimethylated Arg (residues 895-1011) , 2 PHD-type zinc fingers and C-terminal domain. Jmjd2a is Fe+2 and α-ketoglutarate dependent. Methylation of histones in the chromatin is involved in regulation of gene activity, chromatin structure and epigenetic memory<ref>PMID:16677698</ref>.<br /> | |||
'''Jumonji domain-containing protein | '''Jumonji domain-containing protein 2b''' (Jmjd2b) or '''KDM4B''' and '''Jumonji domain-containing protein 2d''' (Jmjd2d) or '''KDM4D''' catalyze the demethylation of trimethylated histone H3 at lysine residues 9 producing the dimethylated form. <br /> | ||
'''Jumonji domain-containing protein 3''' (Jmjd3) or '''KDM6B''' and '''Jumonji domain-containing protein 2d''' (Jmjd2d) or '''KDM4D''' catalyze the demethylation of trimethylated histone H3 at lysine residues 27 producing the dimethylated form<ref>PMID:22308433</ref>. <br /> | |||
'''Jumonji domain-containing protein 5''' (Jmjd5) or '''KDM8''' and '''Jumonji domain-containing protein 6''' (Jmjd6) function as histone demethylase and as a protein hydroxylase.<br /> | |||
== Disease == | == Disease == | ||
Jmjd6 serves as a receptor allowing the foot-and-mouth virus to infect cells<ref>PMID:26896934</ref>. | |||
== Structural highlights == | == Structural highlights == | ||