Hepatocyte growth factor

Function Hepatocyte growth factor (HGF) regulates cell growth, motility and morphogenesis. HGF binds to proto-oncogene c-Met receptor and activates a tyrosine kinase signaling cascade. HGF precursor is cleaved by serine protease to α (69 kD) and β (34 kD) chains which form a disulfide bond to produce the active heterodimer. HGF α chain contains an N-terminal hairpin and 4 kringle domains. The kringle domain participates in protein-protein interaction and its structure is of a large loop which is stabilized by 3 Cys-Cys bonds. HGF β chain is catalytically inactive serine protease-like. HGF NK1 - a natural splice variant is comprised of residues 28-210 containing the N-terminus and the first kringle domain of HGF. HGF NK2 variant is comprised of residues 28-289 containing the N-terminus and the first 2 kringle domains of HGF. Relevance High levels of HGF are associated with liver diseases, lung diseases, acute cardiac infraction, vascular diseases, renal failure, neurologic diseases like Alzheimer Disease, pancreatic diseases, several types of cancer and diabetes type II. HGF administration can reverse liver chirrosis.

spinqualitylabelsall models Structure of human HGF β chain (grey) complex with HGF receptor Sema and ψ domains (green) (PDB entry 1shy) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of hepatocyte growth factor3D structures of hepatocyte growth factor

Updated on 12-June-2017

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• HGF N terminal
  • 2hgf – hHGF N terminal – human - NMR
    
  • 3hms, 3hmt – hHGF N terminal
    
  • 3hmr – mHGF N terminal – mouse
    
• HGF NK1 variant
  • 1bht, 1nk1, 1gp9, 2qj2, 2qj4 – hHGF NK1
    
  • 5cs1, 5cs5, 5cs9, 5coe – hHGF NK1 (mutant)
    
  • 1gmn, 1gmo, 3mkp – hHGF NK1 (mutant) + heparin
    
  • 5ct1, 5ct2, 5ct3, 5cs3, 5csq, 5cp9 – hHGF NK1 (mutant) + inhibitor
    
• HGF NK2 variant
  • 3hn4 – hHGF NK2
    
  • 3sp8 – hHGF NK2 (mutant) + heparin
    
  • 4iua – mHGF NK2 (mutant)
    
• HGF α chain (69 kD)
  • 4o3t, 4o3u – hHGF α chain (mutant) + HGF receptor Sema and ψ domains + zymogen activator peptide
    
• HGF β chain
  • 1si5 – hHGF β chain (mutant)
    
  • 1shy – hHGF β chain (mutant) + HGF receptor Sema and ψ domains
    
• HGF α+β chain
  • 4k3j – hHGF α (mutant) + β + antibody
    

ReferencesReferences