Growth factor receptor-bound protein: Difference between revisions
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<StructureSection load='1bmb' size='350' side='right' caption='Structure of human Grb2 SH2 domain (grey) complex with phosphotyrosyl polypeptide (gold) (PDB entry [[1bmb]])' scene=''> | <StructureSection load='1bmb' size='350' side='right' caption='Structure of human Grb2 SH2 domain (grey) complex with phosphotyrosyl polypeptide (gold) (PDB entry [[1bmb]])' scene=''> | ||
== Function == | |||
'''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> | '''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> | ||
* '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction<ref>PMID:1322798</ref>.<br /> | * '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction<ref>PMID:1322798</ref>.<br /> | ||
* '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway<ref>PMID:19717535</ref>.<br /> | * '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway<ref>PMID:19717535</ref>.<br /> | ||
* '''GRB10''' and '''GRB14''' interact with insulin receptor and insulin-like growth factor receptors<ref>PMID:12783867</ref>. For additional details on GRB10 see [[Grb10 SH2 Domain]].<br /> | * '''GRB10''' and '''GRB14''' interact with insulin receptor and insulin-like growth factor receptors<ref>PMID:12783867</ref>. For additional details on GRB10 see [[Grb10 SH2 Domain]].<br /> | ||
== Structural highlights == | |||
Human GRB2 residue Trp121 forces the phosphotyrosyl containing ligand into a turn conformation<ref>PMID:10090780</ref>. | |||
</StructureSection> | </StructureSection> | ||