Glycolate oxidase: Difference between revisions
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'''Glycolate oxidase''' (GOX) catalyzes the conversion of (S)-2-hydroxy acid and molecular oxygen to 2-oxo acid and hydrogen peroxide. In higher plants, GOX catalyzes the oxidation of glycolate to glyoxylate. GOX is part of the glyoxylate and dicarboxylate metabolism and uses FMN as a cofactor. GOX catalyzes the first step in the utilization of glycolate as the sole source of carbon<ref>PMID:22286136</ref>. | '''Glycolate oxidase''' (GOX) catalyzes the conversion of (S)-2-hydroxy acid and molecular oxygen to 2-oxo acid and hydrogen peroxide. In higher plants, GOX catalyzes the oxidation of glycolate to glyoxylate. GOX is part of the glyoxylate and dicarboxylate metabolism and uses FMN as a cofactor. GOX catalyzes the first step in the utilization of glycolate as the sole source of carbon<ref>PMID:22286136</ref>. | ||
== Disease == | |||
Mutations in GOX result in isolated asymptotic hyperoxaluria type I<ref>PMID:24996905</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
GOX structure shows the typical β8/α8 fold of an α-hydroxy acid oxidase and its active site contains the cofactor FMN<ref>PMID:18215067</ref>. | GOX structure shows the typical β8/α8 fold of an α-hydroxy acid oxidase and its active site contains the cofactor FMN<ref>PMID:18215067</ref>. | ||