1gws: Difference between revisions

Revision as of 18:06, 2 May 2008

HEXADECAHEME HIGH MOLECULAR WEIGHT CYTOCHROME HMC FROM DESULFOVIBRIO VULGARIS HILDENBOROUGH

OverviewOverview

Sulfate-reducing bacteria contain a variety of multi-heme c-type cytochromes. The cytochrome of highest molecular weight (Hmc) contains 16 heme groups and is part of a transmembrane complex involved in the sulfate respiration pathway. We present the 2.42 A resolution crystal structure of the Desulfovibrio vulgaris Hildenborough cytochrome Hmc and a structural model of the complex with its physiological electron transfer partner, cytochrome c(3), obtained by NMR restrained soft-docking calculations. The Hmc is composed of three domains, which exist independently in different sulfate-reducing species, namely cytochrome c(3), cytochrome c(7), and Hcc. The complex involves the last heme at the C-terminal region of the V-shaped Hmc and heme 4 of cytochrome c(3), and represents an example for specific cytochrome-cytochrome interaction.

About this StructureAbout this Structure

1GWS is a Single protein structure of sequence from Desulfovibrio vulgaris. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of the hexadeca-heme cytochrome Hmc and a structural model of its complex with cytochrome c(3)., Czjzek M, ElAntak L, Zamboni V, Morelli X, Dolla A, Guerlesquin F, Bruschi M, Structure. 2002 Dec;10(12):1677-86. PMID:12467575 Page seeded by OCA on Fri May 2 18:06:41 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1gws.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1gws |SIZE=350|CAPTION= <scene name='initialview01'>1gws</scene>, resolution 2.40&Aring;
+The line below this paragraph, containing "STRUCTURE_1gws", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Hec+Binding+Site+For+Residue+A+616'>AC1</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1gws|  PDB=1gws  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gws OCA], [http://www.ebi.ac.uk/pdbsum/1gws PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gws RCSB]</span>
-}}
 '''HEXADECAHEME HIGH MOLECULAR WEIGHT CYTOCHROME HMC FROM DESULFOVIBRIO VULGARIS HILDENBOROUGH'''
@@ Line 28: / Line 25: @@
 [[Category: Czjzek, M.]]
 [[Category: Haser, R.]]
-[[Category: electron transport]]
+[[Category: Electron transport]]
-[[Category: heme]]
+[[Category: Heme]]
-[[Category: multiheme cytochrome]]
+[[Category: Multiheme cytochrome]]
-[[Category: periplasmic,repeat]]
+[[Category: Periplasmic,repeat]]
-[[Category: signal]]
+[[Category: Signal]]
-[[Category: sulfate reducing bacteria]]
+[[Category: Sulfate reducing bacteria]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:06:41 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:52:58 2008''