1gue: Difference between revisions

Revision as of 18:01, 2 May 2008

SENSORY RHODOPSIN II

OverviewOverview

Sensory rhodopsins are the primary receptors of vision in animals and phototaxis in microorganisms. Light triggers the rapid isomerization of a buried retinal chromophore, which the protein both accommodates and amplifies into the larger structural rearrangements required for signaling. We trapped an early intermediate of the photocycle of sensory rhodopsin II from Natronobacterium pharaonis (pSRII) in 3D crystals and determined its X-ray structure to 2.3 A resolution. The observed structural rearrangements were localized near the retinal chromophore, with a key water molecule becoming disordered and the retinal's beta-ionone ring undergoing a prominent movement. Comparison with the early structural rearrangements of bacteriorhodopsin illustrates how modifications in the retinal binding pocket of pSRII allow subtle differences in the early relaxation of photoisomerized retinal.

About this StructureAbout this Structure

1GUE is a Single protein structure of sequence from Natronomonas pharaonis. Full crystallographic information is available from OCA.

ReferenceReference

Early structural rearrangements in the photocycle of an integral membrane sensory receptor., Edman K, Royant A, Nollert P, Maxwell CA, Pebay-Peyroula E, Navarro J, Neutze R, Landau EM, Structure. 2002 Apr;10(4):473-82. PMID:11937052 Page seeded by OCA on Fri May 2 18:01:12 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1gue.gif|left|200px]]
- {{Structure
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-}}
 '''SENSORY RHODOPSIN II'''
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 [[Category: Pebay-Peyroula, E.]]
 [[Category: Royant, A.]]
-[[Category: archaeal rhodopsin]]
+[[Category: Archaeal rhodopsin]]
-[[Category: photoreceptor]]
+[[Category: Photoreceptor]]
-[[Category: phototaxis]]
+[[Category: Phototaxis]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:01:12 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:51:26 2008''