4uc4: Difference between revisions

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'''Unreleased structure'''


The entry 4uc4 is ON HOLD until Mar 10 2017
==Crystal structure of hybrid tudor domain of human lysine demethylase KDM4B==
<StructureSection load='4uc4' size='340' side='right' caption='[[4uc4]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uc4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UC4 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uc4 OCA], [http://pdbe.org/4uc4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uc4 RCSB], [http://www.ebi.ac.uk/pdbsum/4uc4 PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KDM4B_HUMAN KDM4B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>  


Authors: Wang, F., Su, Z., Denu, J.M., Phillips Jr., G.N.
==See Also==
 
*[[Jumonji domain-containing protein|Jumonji domain-containing protein]]
Description: Crystal structure of hybrid tudor domain of human lysine demethylase KDM4B
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: G.N]]
__TOC__
</StructureSection>
[[Category: Denu, J M]]
[[Category: Phillips, G N]]
[[Category: Su, Z]]
[[Category: Su, Z]]
[[Category: Denu, J.M]]
[[Category: Wang, F]]
[[Category: Wang, F]]
[[Category: Phillips Jr]]
[[Category: Chromatin]]
[[Category: Replication]]
[[Category: Tudor]]

Revision as of 06:42, 11 May 2016

Crystal structure of hybrid tudor domain of human lysine demethylase KDM4BCrystal structure of hybrid tudor domain of human lysine demethylase KDM4B

Structural highlights

4uc4 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[KDM4B_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.[1]

See Also

References

  1. ↑ Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell. 2006 May 5;125(3):467-81. Epub 2006 Apr 6. PMID:16603238 doi:10.1016/j.cell.2006.03.028

4uc4, resolution 2.56Å

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