1gp2: Difference between revisions

Revision as of 17:50, 2 May 2008

G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND

OverviewOverview

The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha/beta interface covers switch II of alpha, and GTP-induced rearrangement of switch II causes subunit dissociation during signaling. Alterations in GDP binding in the heterotrimer (compared with alpha-GDP) explain stabilization of the inactive conformation of alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade.

About this StructureAbout this Structure

1GP2 is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2., Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR, Cell. 1995 Dec 15;83(6):1047-58. PMID:8521505 Page seeded by OCA on Fri May 2 17:50:33 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1gp2.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1gp2 |SIZE=350|CAPTION= <scene name='initialview01'>1gp2</scene>, resolution 2.3&Aring;
+The line below this paragraph, containing "STRUCTURE_1gp2", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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-|GENE=
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-|DOMAIN=
+{{STRUCTURE_1gp2|  PDB=1gp2  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gp2 OCA], [http://www.ebi.ac.uk/pdbsum/1gp2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gp2 RCSB]</span>
-}}
 '''G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND'''
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 [[Category: Sprang, S R.]]
 [[Category: Wall, M A.]]
-[[Category: complex (gtp-binding/transducer)]]
+[[Category: Gtpase]]
-[[Category: gtpase]]
+[[Category: Ras-like]]
-[[Category: ras-like]]
+[[Category: Signal transduction protein]]
-[[Category: signal transduction protein]]
+[[Category: Wd40]]
-[[Category: wd40]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:50:33 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:48:29 2008''