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==Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Glutamate== | ==Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Glutamate== | ||
<StructureSection load='4xn1' size='340' side='right' caption='[[4xn1]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4xn1' size='340' side='right'caption='[[4xn1]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4xn1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XN1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4xn1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XN1 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xms|4xms]], [[4xmt|4xmt]], [[4xmu|4xmu]], [[4xmv|4xmv]], [[4xmw|4xmw]], [[4xmx|4xmx]], [[4xmz|4xmz]], [[4xn2|4xn2]], [[4xn4|4xn4]], [[4xn5|4xn5]], [[4xn7|4xn7]], [[4xn8|4xn8]], [[4xn9|4xn9]], [[4xna|4xna]], [[4xnb|4xnb]], [[4xnd|4xnd]], [[4xo3|4xo3]], [[4xo4|4xo4]], [[4xo5|4xo5]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xms|4xms]], [[4xmt|4xmt]], [[4xmu|4xmu]], [[4xmv|4xmv]], [[4xmw|4xmw]], [[4xmx|4xmx]], [[4xmz|4xmz]], [[4xn2|4xn2]], [[4xn4|4xn4]], [[4xn5|4xn5]], [[4xn7|4xn7]], [[4xn8|4xn8]], [[4xn9|4xn9]], [[4xna|4xna]], [[4xnb|4xnb]], [[4xnd|4xnd]], [[4xo3|4xo3]], [[4xo4|4xo4]], [[4xo5|4xo5]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pepN, b0932, JW0915 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane_alanyl_aminopeptidase Membrane alanyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.2 3.4.11.2] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane_alanyl_aminopeptidase Membrane alanyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.2 3.4.11.2] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xn1 OCA], [http://pdbe.org/4xn1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xn1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xn1 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xn1 OCA], [http://pdbe.org/4xn1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xn1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xn1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xn1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/AMPN_ECOLI AMPN_ECOLI]] Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation. | [[http://www.uniprot.org/uniprot/AMPN_ECOLI AMPN_ECOLI]] Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation. | ||
==See Also== | |||
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Ecoli]] | |||
[[Category: Large Structures]] | |||
[[Category: Membrane alanyl aminopeptidase]] | [[Category: Membrane alanyl aminopeptidase]] | ||
[[Category: Addlagatta, A]] | [[Category: Addlagatta, A]] | ||
[[Category: Gumpena, R]] | [[Category: Gumpena, R]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 10:18, 29 May 2019
Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-GlutamateCrystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Glutamate
Structural highlights
Function[AMPN_ECOLI] Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation. See Also |
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