PcrH: Difference between revisions

Revision as of 15:51, 15 February 2016

Function

PcrH or Regulatory protein PcrH is a chaperone protein which is a member of the translocon system which enables bacteria to form a pore in the cell wall for the insertion of toxins into it. See details in Molecular Playground/Pcr H.

Structural highlights

PcrH contains a helical Tpr domain (tetratricopeptide) which interacts with the translocator PopD or PopB peptide^[1]. PopD peptide binds at the concave surface of PcrH.

PcrH (magenta, green) complex with PopD chaperone binding peptide (cyan) and NO3- ion (PDB code 2xcb)

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3D Structures of lactoferrin3D Structures of lactoferrin

Updated on 15-February-2016

2xcc - PaPcrH – Pseudomonas aeruginosa
2xcb - PaPcrH + PopD chaperone-binding peptide
4jl0 - PaPcrH + PopB chaperone-binding peptide

ReferencesReferences

↑ Job V, Mattei PJ, Lemaire D, Attree I, Dessen A. Structural basis of chaperone recognition of type III secretion system minor translocator proteins. J Biol Chem. 2010 Jul 23;285(30):23224-32. Epub 2010 Apr 12. PMID:20385547 doi:10.1074/jbc.M110.111278

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Job V, Mattei PJ, Lemaire D, Attree I, Dessen A. Structural basis of chaperone recognition of type III secretion system minor translocator proteins. J Biol Chem. 2010 Jul 23;285(30):23224-32. Epub 2010 Apr 12. PMID:20385547 doi:10.1074/jbc.M110.111278

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Revision as of 14:39, 15 February 2016 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 15:51, 15 February 2016 view source Alexander Berchansky (talk \| contribs) 29,637 edits No edit summary Newer edit →
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	<StructureSection load='2xcb' size='~~340~~' side='right' caption='PcrH (~~grey~~, green) complex with PopD chaperone binding peptide (~~pink~~) and NO3- ion (PDB code [[2xcb]])' scene=''>		<StructureSection load='2xcb' size='350' side='right' caption='PcrH (magenta, green) complex with PopD chaperone binding peptide (cyan) and NO3- ion (PDB code [[2xcb]])' scene='72/725368/Cv/1'>

	== Function ==		== Function ==