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</StructureSection>
</StructureSection>
__NOTOC__
__NOTOC__
== 3D Structures of Immunoglobulin ==
== 3D structure of antibody ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[3D structures of antibody]]


Humanized mouse antibody (hmFab) is a modified mFab which resembles more hFab.
{{#tree:id=OrganizedByTopic|openlevels=0|
*Fab
**[[7fab]], [[1mco]], [[3na9]], [[3lrs]], [[3mme]], [[3hi5]], [[1vge]], [[3nfs]], [[1ad0]], [[3w9d]], [[4nm4]], [[8fab]], [[1opg]], [[4fnl]], [[4fqh]], [[1om3]], [[1aqk]], [[2hff]], [[2agj]], [[3hc0]], [[3g6a]], [[3dgg]], [[3dif]], [[1b2w]], [[3eyo]], [[3eyq]], [[2aj3]], [[3fzu]], [[3aaz]], [[3gje]] - hFab - human<br />
**[[3naa]], [[3nab]], [[3nac]], [[3ncj]], [[3o2v]], [[3hc3]], [[3hc4]] - hFab (mutant)<br />
**[[3i75]], [[1nqb]], [[1f4w]], [[1aif]], [[1ghf]], [[2z91]], [[1ind]], [[3bkc]], [[3bkm]], [[1iy0]], [[3pp3]], [[3pp4]], [[3okm]], [[6fab]], 2hkh]], [[1ay1]], [[1nbv]], [[1qbm]], [[1bbd]], [[1dsf]], [[1gpo]], [[1mnu]], [[1igf]], [[1for]], [[1k6q]], [[1bz7]], [[1dqd]], [[2ipt]], [[2iq9]], [[2iqa]], [[2w60]], [[2w9d]], [[3iu4]], [[1q9k]], [[1q9l]], [[1q9o]], [[2z4q]], [[1cl7]], [[1n4x]], [[1cr9]], [[1r24]], [[1gig]], [[1uyw]], [[1cgs]], [[2cgr]], [[1q0x]], [[1ibg]], [[3eo0]], [[2op4]], [[2q76]], [[2ojz]], [[2g60]], [[2dbl]], [[1dbj]], [[1dbk]], [[1dbm]], [[1dba]], [[1mrc]], [[2gcy]], [[1flr]], [[1uz6]], [[1rfd]], [[1t2q]], [[1ggb]], [[1ggc]], [[1bm3]], [[2eh7]], [[2fat]], [[3cfc]], [[1fl3]], [[3cfe]], [[4j1u]], [[4gq9]], [[3qg7]], [[3rvt]], [[3s62]], [[4gay]] - mFab – mouse<br />
**[[3eot]], [[2d03]], [[3esv]], [[3et9]] – mFab (mutant)<br />
**[[3iy2]], [[3iy3]], [[3iy4]], [[3iy5]], [[3iy6]], [[3iy7]] - mFab – Cryo EM<br />
**[[1jpt]], [[3mxv]], [[2o5x]], [[1ucb]], [[1bbj]], [[1t04]], [[2fgw]], [[1fvd]], [[1fve]] - hmFab <br />
**[[1cqk]] – mFab MAK33 CH3 domain<br />
**[[3mj8]], [[3r06]] – AhFab – Armenian hamster<br />
**[[3iy1]], [[1zan]] – rFab – rat<br />
**[[4k3e]], [[4k3d]] – bFab – bovine<br />
**[[4b41]], [[1shm]], [[2xa3]] – LgFab – ''Lama glama''<br />
**[[1f2x]] – cFab – camel<br />
*Anti-HIV Fab
**[[1rz7]], [[1rz8]], [[1rzf]], [[1rzg]], [[1rzi]], [[3mlj]], [[3mug]], [[3juy]], [[3qeh]], [[3ttn]], [[rpi]], [[3tnm]], [[4fz8]], [[4f58]], [[4f57]], [[4f5a]] - hFab <br />
**[[3nz8]], [[3o6k]], [[3ntc]], [[3qeg]] – mFab <br />
*Fab: small molecule complex
**[[3o2w]] - hFab 1e9 (mutant) + transition state analog<br />
**[[3ra7]] – mFab + digoxigenin – mouse<br />
**[[3okd]], [[3oke]], [[3okk]], [[3okl]], [[3okn]], [[3oko]], [[3hzk]], [[3hzm]], [[3hzv]], [[3hzy]], [[3pho]], [[3phq]], [[3hns]], [[3hnt]], [[3hnv]]  - mFab + liposaccharide<br />
**[[3oau]] – hFab 2g12 (mutant) + mannose<br />
**[[1ikf]] – hFab R45 + cyclosporin<br />
**[[3oay]], [[3oaz]], [[3ob0]], [[1zls]], [[1zlu]], [[1zlv]], [[1zlw]] - hFab 2g12 + glycan<br />
**[[2jb5]], [[2jb6]] - hFab/mFab + hapten<br />
**[[1ine]], [[1ub5]], [[1ub6]] - mFab + hapten<br />
**[[3ls4]] – mFab + tetrahydrocannabinol<br />
**[[1mfc]], [[1mfd]], [[1mfe]], [[4hgw]] – mFab + polysaccharide<br />
**[[1op3]], [[1op5]] - hFab + polysaccharide<br />
**[[3eyv]] - hFab/mFab 13G5 (mutant) + hapten<br />
**[[2ntf]] - mFab RS2-1G9 + lactone analog<br />
**[[1riu]], [[1riv]], [[1qyg]], [[1q72]] - mFab + cocaine derivative<br />
**[[1ynk]], [[1ynl]], [[1etz]] – mFab + sweetener<br />
**[[1yef]] – mFab D2.3 + substrate analog<br />
**[[1yeg]] - mFab D2.3 + product<br />
**[[1p7k]] – mFab + HEPES<br />
**[[1q0y]] – mFab 9B1 + morphine<br />
**[[1q9q]], [[1q9r]], [[1q9t]], [[1q9v]], [[1q9w]], [[1f4x]], [[1f4y]], [[1mfa]], [[1mfb]] - mFab + carbohydrate<br />
**[[1mex]] – mFab 29G12 + benzoic acid derivative<br />
**[[1mrd]], [[1mre]], [[1mrf]] – mFab JEL103 + nucleotide<br />
**[[1dbb]] – mFab DB3 + progesterone<br />
**[[1igj]] - mFab 26-10 + digoxin<br />
**[[4fab]] – mFab 4-4-20 + fluorescin<br />
**[[1dl7]] - mFab MCPC603 + phosphocholine<br />
**[[3cfb]], [[3cfd]], [[2g2r]] – mFab + stilbene hapten<br />
**[[1i3u]], [[1i3v]] - LgFab + hapten<br />
*Fab: peptide complex
**[[3e8u]] - mFab + BNP peptide<br />
**[[2a6d]], [[2a6i]], [[2a6j]], [[2a6k]] - mFab + peptide<br />
**[[3hr5]] – mFab + M1prime peptide<br />
**[[3eys]], [[3eyu]] - mFab + amyloid-β-related peptide<br />
**[[3ggw]] – mFab + carbohydrate-mimetic peptide<br />
**[[3cxd]], [[3dsf]] – mFab + osteopontin peptide<br />
**[[2zpk]] – mFab + proteinase-activated receptor peptide<br />
**[[3ifl]], [[3ifn]], [[3ifo]], [[3ifp]] - mFab + amyloid peptide<br />
**[[3h0t]] - hFab + hepcidin peptide<br />
**[[1sm3]] - hFab SM3 + peptide<br />
**[[3eyf]] – hFab + cytomegalovirus peptide<br />
**[[2hfg]], [[2h9g]] – hFab + TNF receptor peptide<br />
**[[3csy]] - hFab + Ebola envelope glycoprotein peptide<br />
**[[2eh8]] - mFab + PRES1 peptide<br />
**[[2brr]] – mFab + outer membrane protein peptide<br />
**[[1xgy]] – mFab + rhodopsin peptide<br />
**[[1pz5]] – mFab SYA/J6 + peptide<br />
**[[1a3r]] – mFab + rhinovirus capsid peptide<br />
**[[1cu4]] - mFab + prion protein peptide<br />
**[[1fpt]] – mFab + poliovirus peptide<br />
**[[1jp5]] – mFab + HIV-1 protease peptide<br />
**[[1mvu]] – mFab + glycoprotein <br />
**[[2ap2]] – mFab + glycoprotein peptide + C-myc peptide<br />
**[[2hh0]] – hFab/mFab + prion protein peptide<br />
**[[1frg]], [[1him]], [[1hin]], [[1ifh]] - mFab + hemagglutinin peptide<br />
**[[1tet]] – mFab + cholera toxin peptide<br />
**[[1i8i]], [[1i8k]] – mFab + EGFR peptide<br />
**[[1i8k]] – mFab + EGFR peptide<br />
**[[1i8i]], [[1i8k]] – mFab + EGFR peptide<br />
**[[1i8k]] – mFab + EGFR peptide<br />
**[[4gag]], [[4gaj]] – mFab + genome polyprotein peptide<br />
**[[3bky]] – hFab/mFab + CD20 peptide<br />
**[[4hs8]] – hFab + hepatitis virus peptide <br />
*Anti-HIV Fab: peptide complex
**[[3egs]], [[3drt]], [[3drq]], [[3dro]], [[2fx7]], [[2fx8]], [[2fx9]], [[2cmr]], [[1tzg]], [[1tjg]], [[3mnw]], [[3moa]], [[3mob]], [[3mod]], [[1tjh]], [[1tji]], [[1u8h]], [[1u8i]], [[1u8j]], [[1u8k]], [[1u8l]], [[1u8m]], [[1u8n]], [[1u8o]], [[1u8p]], [[1u8q]], [[1u91]], [[1u92]], [[1u93]], [[1u95]], [[2f5b]] - hFab anti-HIV + gp41 peptide<br />
**[[3ghb]], [[3ghe]], [[3c2a]] - hFab anti-HIV + envelope glycoprotein peptide<br />
**[[3go1]] - hFab anti-HIV + envelope glycoprotein  gp160 peptide<br />
**[[3fn0]], [[2oqj]] - hFab + peptide<br />
**[[2b0s]], [[2b1a]], [[2b1h]], [[3se8]], [[3se9]], [[4jkp]], [[4jpv]], [[4jb9]] - hFab anti-HIV + glycoprotein gp120 peptide<br />
**[[1nak]], [[2f58]], [[3f58]], [[1f58]], [[1acy]], [[1qnz]] - mFab anti-HIV + glycoprotein gp120 peptide<br />
**[[1ai1]], [[1ggi]] – mFab anti-HIV + V3 peptide<br />
**[[3o6l]], [[3o6m]] - mFab 11H6H1 anti-HIV + Tat peptide<br />
**[[1svz]] - mFab anti-HIV + HIV-2 protease peptide<br />
*Fab: protein complex
**[[3raj]] – mFab HB7 + CD38<br />
**[[3o0r]] – mFab + nitric oxide reductase<br />
**[[3mac]], [[3ma9]] – hFab 8062 anti-HIV + transmembrane glycoprotein<br />
**[[3pnw]] – hFab + Tudor domain-containing protein 3<br />
**[[3h42]] - hFab LDLR + proprotein convertase subtilisin/kexin<br />
**[[3nh7]] – hFab ABD1556 + bone morphogenetic protein receptor<br />
**[[3hi6]] – hFab AL-57 + integrin<br />
**[[2vxs]] - hFab + interleukin<br />
**[[3b2u]], [[3b2v]] – hFab IMC-11F8 + EGFR<br />
**[[2r0k]], [[2r0l]] – hFab + HGFA<br />
**[[3ld8]], [[3ldb]] – AhFab + bifunctional arginine demethylase <br />
**[[3be1]], [[3n85]], [[1n8z]] - hFab + ERBB-2<br />
**[[3kr3]] – hFab + IGF-II<br />
**[[3g6d]] – hFab CNTO607 + IL-13<br />
**[[3idx]], [[3idy]], [[2ny7]], [[4jpw]], [[4lsp]], [[4lsq]], [[4lsr]], [[4lss]], [[4lst]], [[4lsu]], [[4lsv]] - hFab + gp120 core<br />
**[[2x7l]] – Fab anti-HIV + HIV REV<br />
**[[3gbm]], [[3gbn]], [[3lzf]], [[3fku]], [[3sdy]], [[3ztj]], [[3ztn]], [[4fp8]], [[4fqi]], [[4fqj]], [[4fqk]], [[4fql]], [[4fqr]], [[4fqv]], [[4fqy]], [[4gxu]], [[4nm8]]- hFab + hemagglutinin<br />
**[[3g6j]] – hFab + complement C3<br />
**[[2vxq]] – hFab + pollen allergen PHL<br />
**[[1fsk]] - mFab + pollen allergen<br />
**[[2wub]], [[3k2u]] – hFab 40 + hepatocyte growth factor activator<br />
**[[3grw]] - hFab + fibroblast growth factor receptor<br />
**[[3bdy]], [[2qr0]], [[2fjg]], [[2fjh]], [[1cz8]] – hFab + VEGF<br />
**[[1tzh]], [[1tzi]] - mFab + VEGF<br />
**[[3bqu]] – hFab 2F5 anti-HIV + mFab 3H6<br />
**[[1adq]] – hFab IGM + igG1 Fc<br />
**[[3dvg]], [[3dvn]] – hFab igG1 + ubiquitin<br />
**[[3bn9]] – hFab E2 + membrane-type serine protease<br />
**[[2jix]] – hFab ABT-007 + erythropoietin receptor<br />
**[[1za3]] - hFab YSD1 + TNF receptor<br />
**[[3l95]] – hFab + NRR1<br />
**[[1uj3]], [[4dtg]] – hFab + tissue factor<br />
**[[3lev]] – hFab 2F5 + RNA polymerase sigma factor<br />
**[[3ru8]] – hFab B12 + epitope scaffold 2BODX43<br />
**[[3skj]] – hFab + ephrin receptor<br />
**[[3sob]] – hFab + LPR6<br />
**[[3vg9]] – hFab + adenosine receptor<br />
**[[3vga]] – hFab + adenosine receptor (mutant)<br />
**[[2qqk]], [[2qql]], [[2qqn]] – hFab + neuropilin<br />
**[[2vyr]] – hFab + MDM4<br />
**[[4c2i]] – hFab + dengue virus envelope protein<br />
**[[4dag]] – hFab + metapneumovirus glycoprotein F0<br />
**[[1jps]] - hmFab D3H44 + tissue factor<br />
**[[1ahw]] - mFab 5G9+ tissue factor<br />
**[[1eo8]], [[1ken]], [[4mhh]], [[4mhj]] - mFab + hemagglutinin<br />
**[[2w9e]], [[1tpx]], [[1tqb]], [[1tqc]] – mFAB + major prion protein<br />
**[[2oz4]] – mFab + intercellular adhesion molecule<br />
**[[3eo1]] - mFab GC-1008 + transforming growth factor β-3<br />
**[[2dtg]] – mFab 83 + insulin receptor<br />
**[[1egj]] – mFab + cytokine receptor<br />
**[[2bdn]] – mFab + cytokine A2<br />
**[[1jrh]] – mFab + interferon-γ receptor<br />
**[[1ob1]] – mFab + major merozoite surface protein<br />
**[[1qfw]] – mFab + gonadotropin<br />
**[[4cad]] – mFab + RCE1<br />
**[[4m48]] – mFab + dopamine transporter<br />
**[[1yjd]] – mFab 5.11A1 + CD28<br />
**[[1sy6]] – mFab OKT3 + CD3<br />
**[[4k4m]], [[4k2u]] – mFab + erythrocyte binding antigen<br />
**[[1afv]] – mFab anti-HIV + capsid protein C<br />
**[[2b2x]] – rFab AQC2 + integrin<br />
**[[2r56]] – bFab igE + β-lactoglobulin <br />
**[[1bzq]], [[2p42]], [[2p43]], [[2p44]], [[2p45]], [[2p46]], [[2p47]], [[2p48]], [[2p49]], [[2p4a]] – bFab Cab-Rn05 + RNase<br />
**[[2r9h]] – mFab + exchange transporter ClCA<br />
**[[1nca]], [[1ncb]], [[1ncc]], [[1ncd]] – mFab + neuraminidase<br />
**[[1rjl]] – mFab + outer surface protein<br />
**[[1mhh]] – mFab + protein L (mutant)<br />
**[[1pg7]] – mFab 6A6 + hmFab D3H44<br />
**[[1pkq]] – hFab/mFab 8-18C5 + myelin glycoprotein<br />
**[[2jel]] – mFab JEL42 + histidine-containing protein<br />
**[[1nsn]] – mFab N10 + nuclease<br />
**[[1rvf]] – mFab 17-IA + intact rhinovirus<br />
**[[3j3o]], [[3j3p]]- mFab + poliovirus proteins – cryoEM<br />
**[[1nfd]] – mFab H57 + T-cell receptor<br />
**[[1igc]] – mFab MOPC21 + streptococcal protein G<br />
**[[1iai]] – mFab idiotipic + mFab anti-idiotypic<br />
**[[2r8s]] – mFab + RNA<br />
**[[2fr4]], [[1xf2]], [[1xf3]], [[1xf4]], [[1i8m]], [[1cbv]] – mFab + DNA<br />
**[[1mhp]], [[3q3g]], [[3qa3]] – mFab  + integrin<br />
**[[3ab0]] – mFab + BCLA protein<br />
**[[3etb]] – mFab M18 (mutant) + anthrax-protective antigen<br />
**[[3f5w]], [[3pjs]], [[3efd]], [[3eff]], [[2hjf]], [[2w0f]], [[4msw]] – mFab + KcsA K+ channel<br />
**[[3stl]], [[3stz]], [[4i9w]] - mFab + KcsA K+ channel (mutant)<br />
**[[1kb5]] – mFab + T-cell receptor<br />
**[[4i18]] – mFab + pro-lactin receptor<br />
**[[1uwx]] – mFab + protein G prime <br />
**[[4ckd]] – mFab + β-galactosidase <br />
**[[3fmg]] – mFab + glycoprotein VP7<br />
**[[3ve0]] - mFab + Ebola envelope glycoprotein<br />
**[[3k7u]], [[3k80]] – LgFab + MP18 RNA editing protein – Lama glama<br />
**[[3mj9]] – AhFab HL4E10 + JAML <br />
**[[3r08]] - AhFab 2C11 + CD3ε<br />
**[[4hti]] – rFab + TNF ligand<br />
**[[1g6v]] – bFab + carbonic anhydrase<br />
**[[4hgk]] – Fab + albumin – shark<br />
**[[4ej1]], [[4eiz]], [[4eig]] – LgFab + DHFR <br />
**[[3k81]], [[3stb]], [[4dk3]], [[4dk6]], [[4dka]] – LgFab + RNA editing complex protein<br />
**[[3p0g]], [[4lde]], [[4ldl]], [[4ldo]] – LgFab + adrenergic receptor<br />
**[[1jto]], [[1jtp]], [[1jtt]], [[1ri8]], [[1xfp]], [[1zmy]], [[1zv5]], [[1zvh]] – cFab + lysozyme<br />
**[[2x89]] – cFab + β-2-microglobulin<br />
**[[4i0c]] – cFab + lysozyme<br />
**[[4ht1]] – Fab + TNF ligand 12 – rabbit<br />
*Fab: protein ternary complex
**[[3ixx]], [[3ixy]] - mFab E53 + envelope glycoprotein + West Nile virus peptide<br />
**[[1g9m]], [[1g9n]], [[1gc1]], [[2i5y]], [[2i60]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]]  - hFab + envelope glycoprotein gp120 + CD4<br />
**[[2wuc]] - hFab 40 + hepatocyte growth factor activator + inhibitor<br />
**[[3lqa]], [[2qad]] - hFab anti-HIV + CD4 + gp160<br />
**[[3d85]] - hFab 7G10 + IL-12 + IL-23<br />
**[[3bt2]] – hFab anti-UPAR + urokinase-type plasminogen activator + vitronectin<br />
**[[3gjf]], [[3hae]] – hFab + β-2-microglobulin + MHC antigen + NYESO peptide<br />
**[[3gb7]], [[2p7t]], [[2h8p]], [[2hfe]], [[2atk]] - mFab + KcsA K+ channel + ion<br />
**[[3or6]], [[3or7]], [[3ogc]], [[3fb7]], [[3f7v]], [[3f7y]], [[3fb5]], [[3fb6]], [[3fb8]], [[3iga]], [[2itc]], [[2itd]], [[2nlj]], [[2bob]], [[2boc]], [[1s5h]], [[1r3i]], [[1r3j]], [[1r3k]], [[1r3l]], [[1k4c]], [[1k4d]], [[3hpl]] - mFab + KcsA K+ channel (mutant) + ion<br />
**[[2fd6]] – mFab ATN-615 + urokinase-type plasminogen activator + urokinase plasminogen receptor<br />
**[[1j5o]] – mFab + reverse transcriptase + DNA<br />
**[[1qkz]] – mFab + protein G prime + major outer membrane protein peptide<br />
**[[2ibz]] – mFab + cytochrome bc1 complex + stigmatellin <br />
**[[3v0a]] – LgFab + BONT/A1 + NTNH<br />
**[[3sn6]] – LgFab + adrenergic receptor + guanine nucleotide-binding protein<br />
**[[4laj]]  - LgFab + envelope glycoprotein gp120 + CD4<br />
*Full Immunoglobulin
**[[1hzh]] - hFab IgG B12<br />
**[[1iga]] - hIgA1 - model<br />
*Fc Fragments
**[[3dnk]] - hFc Igg1br />
**[[1qp1]] – hFc BRE<br />
**[[3muh]] – hFc PG9<br />
**[[4bsv]], [[4bsw]] – hFc heterodimeric (mutant)<br />
**[[1f6a]] -  hFc  IgE + high-affinity receptor Fc (ε) RI (α)<br />
**[[1fp5]] - hFc IgE C ε 3-C ε 4<br />
*Fv Fragments
**[[3dur]], [[3dus]], [[3duu]], [[3dv4]], [[3dv6]] – mFv + Ig-like protein<br />
**[[3h3b]] – mFv + ERBB2<br />
**[[3hb3]] – mFv + cytochrome c oxidase subunit 1-β<br />
**[[1qle]] - mFv + cytochrome c oxidase<br />
**[[3ln9]] – cFv B10<br />
**[[3tpk]] – cFv KW1<br />
**[[3zhd]], [[3zhk]], [[3zhl]] – hFv scaffold<br />
**[[1kxq]] – cFv + α-amylase<br />
**[[1mel]], [[1rjc]], [[1zvy]] – cFv + lysozyme<br />
}}
==References==
==References==
<references />
<references />

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Eric Martz, David Canner, Wayne Decatur, Alexander Berchansky, Michal Harel, Mark Hoelzer
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