3ba7: Difference between revisions
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==Crystal structure of L26N/D28A mutant of Human acidic fibroblast growth factor== | ==Crystal structure of L26N/D28A mutant of Human acidic fibroblast growth factor== | ||
<StructureSection load='3ba7' size='340' side='right' caption='[[3ba7]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='3ba7' size='340' side='right' caption='[[3ba7]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jqz|1jqz]], [[3b9u|3b9u]], [[3ba4|3ba4]], [[3ba5|3ba5]], [[3bad|3bad]], [[3bag|3bag]], [[3bah|3bah]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jqz|1jqz]], [[3b9u|3b9u]], [[3ba4|3ba4]], [[3ba5|3ba5]], [[3bad|3bad]], [[3bag|3bag]], [[3bah|3bah]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ba7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ba7 OCA], [http://pdbe.org/3ba7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ba7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ba7 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ba7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ba7 OCA], [http://pdbe.org/3ba7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ba7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ba7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ba7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/3ba7_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/3ba7_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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[[Category: Blaber, M]] | [[Category: Blaber, M]] | ||
[[Category: Lee, J]] | [[Category: Lee, J]] | ||
[[Category: Acetylation]] | |||
[[Category: Angiogenesis]] | [[Category: Angiogenesis]] | ||
[[Category: Beta-trefoil]] | [[Category: Beta-trefoil]] | ||
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[[Category: Hormone]] | [[Category: Hormone]] | ||
[[Category: Mitogen]] | [[Category: Mitogen]] | ||
[[Category: Polymorphism]] | |||
Revision as of 11:22, 31 October 2018
Crystal structure of L26N/D28A mutant of Human acidic fibroblast growth factorCrystal structure of L26N/D28A mutant of Human acidic fibroblast growth factor
Structural highlights
Function[FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.[1] [2] [3] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedTurn secondary structure is essential to the formation of globular protein architecture. Turn structures are, however, much more complex than either alpha-helix or beta-sheet, and the thermodynamics and folding kinetics are poorly understood. Type I beta-turns are the most common type of reverse turn, and they exhibit a statistical consensus sequence of Asx-Pro-Asx-Gly (where Asx is Asp or Asn). A comprehensive series of individual and combined Asx mutations has been constructed within three separate type I 3:5 G1 bulge beta-turns in human fibroblast growth factor-1, and their effects on structure, stability, and folding have been determined. The results show a fundamental logical OR relationship between the Asx residues in the motif, involving H-bond interactions with main-chain amides within the turn. These interactions can be modulated by additional interactions with residues adjacent to the turn at positions i+4 and i+6. The results show that the Asx residues in the turn motif make a substantial contribution to the overall stability of the protein, and the Asx logical OR relationship defines a redundant system that can compensate for deleterious point mutations. The results also show that the stability of the turn is unlikely to be the prime determinant of formation of turn structure in the folding transition state. A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.,Lee J, Dubey VK, Longo LM, Blaber M J Mol Biol. 2008 Apr 4;377(4):1251-64. Epub 2008 Jan 31. PMID:18308335[4] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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