1fin: Difference between revisions

Revision as of 16:22, 2 May 2008

CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX

OverviewOverview

The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds to one side of CDK2's catalytic cleft, inducing large conformational changes in its PSTAIRE helix and T-loop. These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft.

About this StructureAbout this Structure

1FIN is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:7630397 Page seeded by OCA on Fri May 2 16:22:19 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1fin.jpg|left|200px]]
- {{Structure
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-}}
 '''CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX'''
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 [[Category: Pavletich, N P.]]
 [[Category: Russo, A A.]]
-[[Category: cdk]]
+[[Category: Cdk]]
-[[Category: complex (transferase/cyclin)]]
+[[Category: Cyclin]]
-[[Category: cyclin]]
+[[Category: Phosphorylation]]
-[[Category: phosphorylation]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:22:19 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:23:38 2008''