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==Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase== | ==Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase== | ||
<StructureSection load='2r4h' size='340' side='right' caption='[[2r4h]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='2r4h' size='340' side='right' caption='[[2r4h]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2q9v|2q9v]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2q9v|2q9v]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [http://pdbe.org/2r4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [http://www.ebi.ac.uk/pdbsum/2r4h PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [http://pdbe.org/2r4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [http://www.ebi.ac.uk/pdbsum/2r4h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4h ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4h ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:42, 25 October 2017
Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinaseCrystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase
Structural highlights
Function[MAGI1_HUMAN] May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Human
- Arrowsmith, C H
- Cooper, C
- Delft, F von
- Doyle, D A
- Edwards, A M
- Elkins, J M
- Hozjan, V
- Kavanagh, K L
- Oppermann, U
- Pike, A C.W
- Pilka, E S
- Structural genomic
- Sundstrom, M
- Ugochukwu, E
- Weigelt, J
- Atp-binding
- Cell junction
- Membrane associated guanylate kinase
- Nucleotide-binding
- Pdz
- Phosphorylation
- Sgc
- Tight junction
- Transferase