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'''CRYSTAL STRUCTURE OF MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN''' | '''CRYSTAL STRUCTURE OF MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN''' | ||
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[[Category: Cygler, M.]] | [[Category: Cygler, M.]] | ||
[[Category: Huang, W.]] | [[Category: Huang, W.]] | ||
[[Category: | [[Category: Bsgi]] | ||
[[Category: | [[Category: Four module]] | ||
[[Category: | [[Category: Molybdopterin]] | ||
[[Category: | [[Category: Montreal-kingston bacterial structural genomics initiative]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: | [[Category: With magnesium]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:09:26 2008'' | |||
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Revision as of 16:09, 2 May 2008
CRYSTAL STRUCTURE OF MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN
OverviewOverview
MoeA is involved in synthesis of the molybdopterin cofactor, although its function is not yet clearly defined. The three-dimensional structure of the Escherichia coli protein was solved at 2.2 A resolution. The locations of highly conserved residues among the prokaryotic and eukaryotic MoeA homologs identifies a cleft in the dimer interface as the likely functional site. Of the four domains of MoeA, domain 2 displays a novel fold and domains 1 and 4 each have only one known structural homolog. Domain 3, in contrast, is structurally similar to many other proteins. The protein that resembles domain 3 most closely is MogA, another protein required for molybdopterin cofactor synthesis. The overall similarity between MoeA and MogA, and the similarities in a constellation of residues that are strongly conserved in MoeA, suggests that these proteins bind similar ligands or substrates and may have similar functions.
About this StructureAbout this Structure
1FC5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of Escherichia coli MoeA, a protein from the molybdopterin synthesis pathway., Schrag JD, Huang W, Sivaraman J, Smith C, Plamondon J, Larocque R, Matte A, Cygler M, J Mol Biol. 2001 Jul 6;310(2):419-31. PMID:11428898 Page seeded by OCA on Fri May 2 16:09:26 2008