3ckk: Difference between revisions

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==Crystal structure of human methyltransferase-like protein 1==
==Crystal structure of human methyltransferase-like protein 1==
<StructureSection load='3ckk' size='340' side='right' caption='[[3ckk]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='3ckk' size='340' side='right' caption='[[3ckk]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">METTL1, C12orf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">METTL1, C12orf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(46)-N(7))-methyltransferase tRNA (guanine(46)-N(7))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.33 2.1.1.33] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(46)-N(7))-methyltransferase tRNA (guanine(46)-N(7))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.33 2.1.1.33] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckk OCA], [http://pdbe.org/3ckk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ckk RCSB], [http://www.ebi.ac.uk/pdbsum/3ckk PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckk OCA], [http://pdbe.org/3ckk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ckk RCSB], [http://www.ebi.ac.uk/pdbsum/3ckk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/3ckk_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/3ckk_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>

Revision as of 16:43, 7 November 2018

Crystal structure of human methyltransferase-like protein 1Crystal structure of human methyltransferase-like protein 1

Structural highlights

3ckk is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:METTL1, C12orf1 (HUMAN)
Activity:tRNA (guanine(46)-N(7))-methyltransferase, with EC number 2.1.1.33
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TRMB_HUMAN] Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Alexandrov A, Martzen MR, Phizicky EM. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. RNA. 2002 Oct;8(10):1253-66. PMID:12403464

3ckk, resolution 1.55Å

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OCA