2c6a: Difference between revisions
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== | |||
==Solution structure of the C4 zinc-finger domain of HDM2== | |||
<StructureSection load='2c6a' size='340' side='right' caption='[[2c6a]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2c6a' size='340' side='right' caption='[[2c6a]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rv1|1rv1]], [[1t4e|1t4e]], [[1t4f|1t4f]], [[1ycr|1ycr]], [[1z1m|1z1m]], [[2c6b|2c6b]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rv1|1rv1]], [[1t4e|1t4e]], [[1t4f|1t4f]], [[1ycr|1ycr]], [[1z1m|1z1m]], [[2c6b|2c6b]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6a OCA], [http://pdbe.org/2c6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c6a RCSB], [http://www.ebi.ac.uk/pdbsum/2c6a PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6a OCA], [http://pdbe.org/2c6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c6a RCSB], [http://www.ebi.ac.uk/pdbsum/2c6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c6a ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/2c6a_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/2c6a_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 2c6a" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2c6a" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Fersht, A R]] | [[Category: Fersht, A R]] | ||
[[Category: Yu, G W]] | [[Category: Yu, G W]] | ||
[[Category: Alternative splicing]] | |||
[[Category: Human mdm2]] | [[Category: Human mdm2]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
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[[Category: Proto- oncogene]] | [[Category: Proto- oncogene]] | ||
[[Category: Ubl conjugation pathway]] | [[Category: Ubl conjugation pathway]] | ||
[[Category: Zinc]] | |||
[[Category: Zinc finger]] | [[Category: Zinc finger]] | ||
Revision as of 21:46, 24 January 2018
Solution structure of the C4 zinc-finger domain of HDM2Solution structure of the C4 zinc-finger domain of HDM2
Structural highlights
Disease[MDM2_HUMAN] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. Function[MDM2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedHDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif. Solution structure of the C4 zinc finger domain of HDM2.,Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M Protein Sci. 2006 Feb;15(2):384-9. Epub 2005 Dec 29. PMID:16385008[12] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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