1eo1: Difference between revisions

Revision as of 15:19, 2 May 2008

Solution structure of hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum

OverviewOverview

The solution structure of MTH1175, a 124-residue protein from the archaeon Methanobacterium thermoautotrophicum has been determined by NMR spectroscopy. MTH1175 is part of a family of conserved hypothetical proteins (COG1433) with unknown functions which contains multiple paralogs from all complete archaeal genomes and the archaeal gene-rich bacterium Thermotoga maritima. Sequence similarity indicates this protein family may be related to the nitrogen fixation proteins NifB and NifX. MTH1175 adopts an alpha/beta topology with a single mixed beta-sheet, and contains two flexible loops and an unstructured C-terminal tail. The fold resembles that of Ribonuclease H and similar proteins, but differs from these in several respects, and is not likely to have a nuclease activity.

About this StructureAbout this Structure

1EO1 is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

ReferenceReference

NMR structure determination and structure-based functional characterization of conserved hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum., Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA, J Struct Funct Genomics. 2000;1(1):15-25. PMID:12836677 Page seeded by OCA on Fri May 2 15:19:47 2008

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OCA

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 '''Solution structure of hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum'''
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 [[Category: Kennedy, M A.]]
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-[[Category: mixed a/b protein]]
+[[Category: Mixed a/b protein]]
-[[Category: mixed beta sheet]]
+[[Category: Mixed beta sheet]]
-[[Category: nesg]]
+[[Category: Nesg]]
-[[Category: northeast structural genomics consortium]]
+[[Category: Northeast structural genomics consortium]]
-[[Category: protein structure initiative]]
+[[Category: Protein structure initiative]]
-[[Category: psi]]
+[[Category: Psi]]
-[[Category: strand order 321456,strands 2 and 6 antiparallel to rest.]]
+[[Category: Strand order 321456,strands 2 and 6 antiparallel to rest.]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:19:47 2008''
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