2zn7: Difference between revisions

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==CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes==
==CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes==
<StructureSection load='2zn7' size='340' side='right' caption='[[2zn7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2zn7' size='340' side='right' caption='[[2zn7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zn7 OCA], [http://pdbe.org/2zn7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zn7 RCSB], [http://www.ebi.ac.uk/pdbsum/2zn7 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zn7 OCA], [http://pdbe.org/2zn7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zn7 RCSB], [http://www.ebi.ac.uk/pdbsum/2zn7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zn7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zn7 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zn7 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Wu, J]]
[[Category: Wu, J]]
[[Category: Xu, W]]
[[Category: Xu, W]]
[[Category: Acetylation]]
[[Category: Endoplasmic reticulum]]
[[Category: Endoplasmic reticulum]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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[[Category: Oxidation]]
[[Category: Oxidation]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protein phosphatase]]
[[Category: Protein phosphatase]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
[[Category: Ptp1b]]
[[Category: Ptp1b]]

Revision as of 13:00, 12 October 2017

CRYSTAL STRUCTURES OF PTP1B-Inhibitor ComplexesCRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes

Structural highlights

2zn7 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:PTP1B (HUMAN)
Activity:Protein-tyrosine-phosphatase, with EC number 3.1.3.48
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Nievergall E, Janes PW, Stegmayer C, Vail ME, Haj FG, Teng SW, Neel BG, Bastiaens PI, Lackmann M. PTP1B regulates Eph receptor function and trafficking. J Cell Biol. 2010 Dec 13;191(6):1189-203. doi: 10.1083/jcb.201005035. Epub 2010, Dec 6. PMID:21135139 doi:10.1083/jcb.201005035
  2. ↑ Krishnan N, Fu C, Pappin DJ, Tonks NK. H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal. 2011 Dec 13;4(203):ra86. doi: 10.1126/scisignal.2002329. PMID:22169477 doi:10.1126/scisignal.2002329

2zn7, resolution 2.10Å

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