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==Crystal structure of E.coli RNase HI active site mutant (E48A/K87A)== | ==Crystal structure of E.coli RNase HI active site mutant (E48A/K87A)== | ||
<StructureSection load='1wsh' size='340' side='right' caption='[[1wsh]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='1wsh' size='340' side='right' caption='[[1wsh]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wse|1wse]], [[1wsf|1wsf]], [[1wsg|1wsg]], [[1wsi|1wsi]], [[1wsj|1wsj]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wse|1wse]], [[1wsf|1wsf]], [[1wsg|1wsg]], [[1wsi|1wsi]], [[1wsj|1wsj]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_H Ribonuclease H], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.4 3.1.26.4] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_H Ribonuclease H], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.4 3.1.26.4] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsh OCA], [http://pdbe.org/1wsh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wsh RCSB], [http://www.ebi.ac.uk/pdbsum/1wsh PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsh OCA], [http://pdbe.org/1wsh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wsh RCSB], [http://www.ebi.ac.uk/pdbsum/1wsh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wsh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/1wsh_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/1wsh_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
Revision as of 19:40, 11 April 2018
Crystal structure of E.coli RNase HI active site mutant (E48A/K87A)Crystal structure of E.coli RNase HI active site mutant (E48A/K87A)
Structural highlights
Function[RNH_ECOLI] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer.[HAMAP-Rule:MF_00042] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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