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==Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055== | ==Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055== | ||
<StructureSection load='3jtk' size='340' side='right' caption='[[3jtk]], [[Resolution|resolution]] 1.61Å' scene=''> | <StructureSection load='3jtk' size='340' side='right' caption='[[3jtk]], [[Resolution|resolution]] 1.61Å' scene=''> | ||
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NMT, NMT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NMT, NMT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jtk OCA], [http://pdbe.org/3jtk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jtk RCSB], [http://www.ebi.ac.uk/pdbsum/3jtk PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jtk OCA], [http://pdbe.org/3jtk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jtk RCSB], [http://www.ebi.ac.uk/pdbsum/3jtk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jtk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/3jtk_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/3jtk_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
Revision as of 12:24, 26 December 2018
Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055
Structural highlights
Function[NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Glycylpeptide N-tetradecanoyltransferase
- Human
- Arrowsmith, C H
- Bochkarev, A
- Bountra, C
- Brand, S Y
- Cossar, D
- Edwards, A M
- Ferguson, M A.J
- Frearson, J A
- Hui, R
- Hutchinson, A
- Kania, A
- Kozieradzki, I
- Lin, Y H
- Qiu, W
- Ravichandran, M
- Robinson, D A
- Structural genomic
- Schapira, M
- Weigelt, J
- Wernimont, A
- Wyatt, P G
- Acyltransferase
- N-myristoyltransferase
- Nmt1
- Phosphoprotein
- Sgc
- Transferase