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==Crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase==
==Crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase==
<StructureSection load='2qnk' size='340' side='right' caption='[[2qnk]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='2qnk' size='340' side='right' caption='[[2qnk]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HAAO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HAAO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyanthranilate_3,4-dioxygenase 3-hydroxyanthranilate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.6 1.13.11.6] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyanthranilate_3,4-dioxygenase 3-hydroxyanthranilate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.6 1.13.11.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qnk OCA], [http://pdbe.org/2qnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qnk RCSB], [http://www.ebi.ac.uk/pdbsum/2qnk PDBsum], [http://www.topsan.org/Proteins/CESG/2qnk TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qnk OCA], [http://pdbe.org/2qnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qnk RCSB], [http://www.ebi.ac.uk/pdbsum/2qnk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qnk ProSAT], [http://www.topsan.org/Proteins/CESG/2qnk TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qnk ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qnk ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Dioxygenase|Dioxygenase]]
== References ==
== References ==
<references/>
<references/>

Revision as of 10:30, 25 October 2017

Crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenaseCrystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase

Structural highlights

2qnk is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
NonStd Res:
Gene:HAAO (HUMAN)
Activity:3-hydroxyanthranilate 3,4-dioxygenase, with EC number 1.13.11.6
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[3HAO_HUMAN] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Malherbe P, Kohler C, Da Prada M, Lang G, Kiefer V, Schwarcz R, Lahm HW, Cesura AM. Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase. J Biol Chem. 1994 May 13;269(19):13792-7. PMID:7514594

2qnk, resolution 1.60Å

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