2wi6: Difference between revisions
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== | |||
==Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone== | |||
<StructureSection load='2wi6' size='340' side='right' caption='[[2wi6]], [[Resolution|resolution]] 2.18Å' scene=''> | <StructureSection load='2wi6' size='340' side='right' caption='[[2wi6]], [[Resolution|resolution]] 2.18Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZZ6:2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>ZZ6</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZZ6:2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>ZZ6</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yes|1yes]], [[1uy9|1uy9]], [[2cdd|2cdd]], [[1byq|1byq]], [[1osf|1osf]], [[2bsm|2bsm]], [[1uy8|1uy8]], [[2bug|2bug]], [[2uwd|2uwd]], [[2bt0|2bt0]], [[1yer|1yer]], [[1uyg|1uyg]], [[2ccu|2ccu]], [[2bz5|2bz5]], [[2ccs|2ccs]], [[1uyf|1uyf]], [[1yc3|1yc3]], [[1uyi|1uyi]], [[1uyd|1uyd]], [[2byi|2byi]], [[1uy6|1uy6]], [[2vci|2vci]], [[2vcj|2vcj]], [[1yc4|1yc4]], [[2c2l|2c2l]], [[1uyh|1uyh]], [[1uyk|1uyk]], [[2cct|2cct]], [[1uyl|1uyl]], [[1uye|1uye]], [[1yc1|1yc1]], [[1uy7|1uy7]], [[1uyc|1uyc]], [[1yet|1yet]], [[2jjc|2jjc]], [[2byh|2byh]], [[2wi4|2wi4]], [[2wi2|2wi2]], [[2wi7|2wi7]], [[2wi3|2wi3]], [[2wi1|2wi1]], [[2wi5|2wi5]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yes|1yes]], [[1uy9|1uy9]], [[2cdd|2cdd]], [[1byq|1byq]], [[1osf|1osf]], [[2bsm|2bsm]], [[1uy8|1uy8]], [[2bug|2bug]], [[2uwd|2uwd]], [[2bt0|2bt0]], [[1yer|1yer]], [[1uyg|1uyg]], [[2ccu|2ccu]], [[2bz5|2bz5]], [[2ccs|2ccs]], [[1uyf|1uyf]], [[1yc3|1yc3]], [[1uyi|1uyi]], [[1uyd|1uyd]], [[2byi|2byi]], [[1uy6|1uy6]], [[2vci|2vci]], [[2vcj|2vcj]], [[1yc4|1yc4]], [[2c2l|2c2l]], [[1uyh|1uyh]], [[1uyk|1uyk]], [[2cct|2cct]], [[1uyl|1uyl]], [[1uye|1uye]], [[1yc1|1yc1]], [[1uy7|1uy7]], [[1uyc|1uyc]], [[1yet|1yet]], [[2jjc|2jjc]], [[2byh|2byh]], [[2wi4|2wi4]], [[2wi2|2wi2]], [[2wi7|2wi7]], [[2wi3|2wi3]], [[2wi1|2wi1]], [[2wi5|2wi5]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wi6 OCA], [http://pdbe.org/2wi6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wi6 RCSB], [http://www.ebi.ac.uk/pdbsum/2wi6 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wi6 OCA], [http://pdbe.org/2wi6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wi6 RCSB], [http://www.ebi.ac.uk/pdbsum/2wi6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wi6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wi6_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wi6_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||