1diw: Difference between revisions

Revision as of 13:53, 2 May 2008

THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE

OverviewOverview

The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.

About this StructureAbout this Structure

1DIW is a Single protein structure of sequence from Clostridium tetani. Full crystallographic information is available from OCA.

ReferenceReference

The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:10722735 Page seeded by OCA on Fri May 2 13:53:50 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1diw.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1diw |SIZE=350|CAPTION= <scene name='initialview01'>1diw</scene>, resolution 2.0&Aring;
+The line below this paragraph, containing "STRUCTURE_1diw", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1diw|  PDB=1diw  |  SCENE=  }}
-|RELATEDENTRY=[[1af9|1AF9]], [[1a8d|1A8D]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1diw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1diw OCA], [http://www.ebi.ac.uk/pdbsum/1diw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1diw RCSB]</span>
-}}
 '''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE'''
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 [[Category: Isaacs, N W.]]
 [[Category: Watts, C.]]
-[[Category: beta trefoil]]
+[[Category: Beta trefoil]]
-[[Category: jelly-roll]]
+[[Category: Jelly-roll]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:53:50 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:42:21 2008''