1dan: Difference between revisions

Revision as of 13:37, 2 May 2008

COMPLEX OF ACTIVE SITE INHIBITED HUMAN BLOOD COAGULATION FACTOR VIIA WITH HUMAN RECOMBINANT SOLUBLE TISSUE FACTOR

OverviewOverview

Blood coagulation is initiated when tissue factor binds to coagulation factor VIIa to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation and clot formation. We have determined the crystal structure at 2.0-A degrees resolution of active-site-inhibited factor VIIa complexed with the cleaved extracellular domain of tissue factor. In the complex, factor VIIa adopts an extended conformation. This structure provides a basis for understanding many molecular aspects of the initiation of coagulation.

About this StructureAbout this Structure

1DAN is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1DAN with [Tissue Factor]. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor., Banner DW, D'Arcy A, Chene C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D, Nature. 1996 Mar 7;380(6569):41-6. PMID:8598903 Page seeded by OCA on Fri May 2 13:37:55 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1dan.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1dan |SIZE=350|CAPTION= <scene name='initialview01'>1dan</scene>, resolution 2.00&Aring;
+The line below this paragraph, containing "STRUCTURE_1dan", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=CH2:METHYLENE+GROUP'>CH2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1dan|  PDB=1dan  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dan OCA], [http://www.ebi.ac.uk/pdbsum/1dan PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dan RCSB]</span>
-}}
 '''COMPLEX OF ACTIVE SITE INHIBITED HUMAN BLOOD COAGULATION FACTOR VIIA WITH HUMAN RECOMBINANT SOLUBLE TISSUE FACTOR'''
@@ Line 28: / Line 25: @@
 [[Category: Tissue Factor]]
 [[Category: Banner, D W.]]
-[[Category: blood coagulation]]
+[[Category: Blood coagulation]]
-[[Category: co-factor]]
+[[Category: Co-factor]]
-[[Category: complex]]
+[[Category: Complex]]
-[[Category: complex (serine protease/cofactor/ligand)]]
+[[Category: Egf]]
-[[Category: egf]]
+[[Category: Gla]]
-[[Category: gla]]
+[[Category: Inhibitor]]
-[[Category: inhibitor]]
+[[Category: Receptor enzyme]]
-[[Category: receptor enzyme]]
+[[Category: Serine protease]]
-[[Category: serine protease]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:37:55 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:37:50 2008''