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==THE STRUCTURE OF A MIXED GLUR2 LIGAND-BINDING CORE DIMER IN COMPLEX WITH (S)-GLUTAMATE AND THE ANTAGONIST (S)-NS1209==
 
==The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209==
<StructureSection load='2cmo' size='340' side='right' caption='[[2cmo]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='2cmo' size='340' side='right' caption='[[2cmo]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ftj|1ftj]], [[1ftk|1ftk]], [[1ftl|1ftl]], [[1ftm|1ftm]], [[1fto|1fto]], [[1fw0|1fw0]], [[1gr2|1gr2]], [[1lb8|1lb8]], [[1lb9|1lb9]], [[1lbb|1lbb]], [[1lbc|1lbc]], [[1m5b|1m5b]], [[1m5c|1m5c]], [[1m5d|1m5d]], [[1m5e|1m5e]], [[1m5f|1m5f]], [[1mm6|1mm6]], [[1mm7|1mm7]], [[1mqd|1mqd]], [[1mqg|1mqg]], [[1mqh|1mqh]], [[1mqi|1mqi]], [[1mqj|1mqj]], [[1ms7|1ms7]], [[1mxu|1mxu]], [[1mxv|1mxv]], [[1mxw|1mxw]], [[1mxx|1mxx]], [[1mxy|1mxy]], [[1mxz|1mxz]], [[1my0|1my0]], [[1my1|1my1]], [[1my2|1my2]], [[1my3|1my3]], [[1my4|1my4]], [[1n0t|1n0t]], [[1nnk|1nnk]], [[1nnp|1nnp]], [[1p1n|1p1n]], [[1p1o|1p1o]], [[1p1q|1p1q]], [[1p1u|1p1u]], [[1p1w|1p1w]], [[1syh|1syh]], [[1syi|1syi]], [[1wvj|1wvj]], [[1xhy|1xhy]], [[2aix|2aix]], [[2al4|2al4]], [[2al5|2al5]], [[2anj|2anj]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ftj|1ftj]], [[1ftk|1ftk]], [[1ftl|1ftl]], [[1ftm|1ftm]], [[1fto|1fto]], [[1fw0|1fw0]], [[1gr2|1gr2]], [[1lb8|1lb8]], [[1lb9|1lb9]], [[1lbb|1lbb]], [[1lbc|1lbc]], [[1m5b|1m5b]], [[1m5c|1m5c]], [[1m5d|1m5d]], [[1m5e|1m5e]], [[1m5f|1m5f]], [[1mm6|1mm6]], [[1mm7|1mm7]], [[1mqd|1mqd]], [[1mqg|1mqg]], [[1mqh|1mqh]], [[1mqi|1mqi]], [[1mqj|1mqj]], [[1ms7|1ms7]], [[1mxu|1mxu]], [[1mxv|1mxv]], [[1mxw|1mxw]], [[1mxx|1mxx]], [[1mxy|1mxy]], [[1mxz|1mxz]], [[1my0|1my0]], [[1my1|1my1]], [[1my2|1my2]], [[1my3|1my3]], [[1my4|1my4]], [[1n0t|1n0t]], [[1nnk|1nnk]], [[1nnp|1nnp]], [[1p1n|1p1n]], [[1p1o|1p1o]], [[1p1q|1p1q]], [[1p1u|1p1u]], [[1p1w|1p1w]], [[1syh|1syh]], [[1syi|1syi]], [[1wvj|1wvj]], [[1xhy|1xhy]], [[2aix|2aix]], [[2al4|2al4]], [[2al5|2al5]], [[2anj|2anj]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [http://pdbe.org/2cmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [http://www.ebi.ac.uk/pdbsum/2cmo PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [http://pdbe.org/2cmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [http://www.ebi.ac.uk/pdbsum/2cmo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmo ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cmo_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cmo_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2cmo" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2cmo" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ionotropic Glutamate Receptors|Ionotropic Glutamate Receptors]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Sigurskjold, B W]]
[[Category: Sigurskjold, B W]]
[[Category: Watjen, F]]
[[Category: Watjen, F]]
[[Category: Alternative splicing]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Ion channel]]
[[Category: Ion channel]]

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