2pxx: Difference between revisions

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==Human putative methyltransferase MGC2408==
==Human putative methyltransferase MGC2408==
<StructureSection load='2pxx' size='340' side='right' caption='[[2pxx]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='2pxx' size='340' side='right' caption='[[2pxx]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MGC2408 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MGC2408 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxx OCA], [http://pdbe.org/2pxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pxx RCSB], [http://www.ebi.ac.uk/pdbsum/2pxx PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxx OCA], [http://pdbe.org/2pxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pxx RCSB], [http://www.ebi.ac.uk/pdbsum/2pxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pxx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==

Revision as of 12:34, 18 October 2017

Human putative methyltransferase MGC2408Human putative methyltransferase MGC2408

Structural highlights

2pxx is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:MGC2408 (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ECE2_HUMAN] Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Mzhavia N, Pan H, Che FY, Fricker LD, Devi LA. Characterization of endothelin-converting enzyme-2. Implication for a role in the nonclassical processing of regulatory peptides. J Biol Chem. 2003 Apr 25;278(17):14704-11. Epub 2003 Jan 30. PMID:12560336 doi:http://dx.doi.org/10.1074/jbc.M211242200

2pxx, resolution 1.30Å

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