1cnp: Difference between revisions

Revision as of 12:55, 2 May 2008

THE STRUCTURE OF CALCYCLIN REVEALS A NOVEL HOMODIMERIC FOLD FOR S100 CA2+-BINDING PROTEINS, NMR, 22 STRUCTURES

OverviewOverview

The S100 calcium-binding proteins are implicated as effectors in calcium-mediated signal transduction pathways. The three-dimensional structure of the S100 protein calcyclin has been determined in solution in the apo state by NMR spectroscopy and a computational strategy that incorporates a systematic docking protocol. This structure reveals a symmetric homodimeric fold that is unique among calcium-binding proteins. Dimerization is mediated by hydrophobic contacts from several highly conserved residues, which suggests that the dimer fold identified for calcyclin will serve as a structural paradigm for the S100 subfamily of calcium-binding proteins.

About this StructureAbout this Structure

1CNP is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

ReferenceReference

The structure of calcyclin reveals a novel homodimeric fold for S100 Ca(2+)-binding proteins., Potts BC, Smith J, Akke M, Macke TJ, Okazaki K, Hidaka H, Case DA, Chazin WJ, Nat Struct Biol. 1995 Sep;2(9):790-6. PMID:7552751 Page seeded by OCA on Fri May 2 12:55:26 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1cnp.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1cnp |SIZE=350|CAPTION= <scene name='initialview01'>1cnp</scene>
+The line below this paragraph, containing "STRUCTURE_1cnp", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=LO1:Ion+Binding+Site'>LO1</scene>, <scene name='pdbsite=LO2:Ion+Binding+Site'>LO2</scene>, <scene name='pdbsite=LO3:Ion+Binding+Site'>LO3</scene> and <scene name='pdbsite=LO4:Ion+Binding+Site'>LO4</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND=
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1cnp|  PDB=1cnp  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cnp OCA], [http://www.ebi.ac.uk/pdbsum/1cnp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cnp RCSB]</span>
-}}
 '''THE STRUCTURE OF CALCYCLIN REVEALS A NOVEL HOMODIMERIC FOLD FOR S100 CA2+-BINDING PROTEINS, NMR, 22 STRUCTURES'''
@@ Line 33: / Line 30: @@
 [[Category: Potts, B C.M.]]
 [[Category: Smith, J.]]
-[[Category: calcium-binding protein]]
+[[Category: Calcium-binding protein]]
-[[Category: ef-hand]]
+[[Category: Ef-hand]]
-[[Category: s-100 protein]]
+[[Category: S-100 protein]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:55:26 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:25:05 2008''