3fxo: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 1 mM of Mn2+== | ==Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 1 mM of Mn2+== | ||
<StructureSection load='3fxo' size='340' side='right' caption='[[3fxo]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3fxo' size='340' side='right' caption='[[3fxo]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| Line 6: | Line 7: | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fxj|3fxj]], [[3fxk|3fxk]], [[3fxl|3fxl]], [[3fxm|3fxm]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fxj|3fxj]], [[3fxk|3fxk]], [[3fxl|3fxl]], [[3fxm|3fxm]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fxo OCA], [http://pdbe.org/3fxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fxo RCSB], [http://www.ebi.ac.uk/pdbsum/3fxo PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fxo OCA], [http://pdbe.org/3fxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fxo RCSB], [http://www.ebi.ac.uk/pdbsum/3fxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fxo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| Line 14: | Line 15: | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/3fxo_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/3fxo_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 34: | Line 35: | ||
[[Category: Wang, K]] | [[Category: Wang, K]] | ||
[[Category: Wang, L]] | [[Category: Wang, L]] | ||
[[Category: Alternative splicing]] | |||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Magnesium]] | [[Category: Magnesium]] | ||
Revision as of 10:52, 5 December 2018
Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 1 mM of Mn2+Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 1 mM of Mn2+
Structural highlights
Function[PPM1A_HUMAN] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
|
| ||||||||||||||||||||