1q9k: Difference between revisions
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==S25-2 Fab Unliganded 1== | ==S25-2 Fab Unliganded 1== | ||
<StructureSection load='1q9k' size='340' side='right' caption='[[1q9k]], [[Resolution|resolution]] 1.96Å' scene=''> | <StructureSection load='1q9k' size='340' side='right' caption='[[1q9k]], [[Resolution|resolution]] 1.96Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1q9l|1q9l]], [[1q9o|1q9o]], [[1q9q|1q9q]], [[1q9r|1q9r]], [[1q9t|1q9t]], [[1q9v|1q9v]], [[1q9w|1q9w]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1q9l|1q9l]], [[1q9o|1q9o]], [[1q9q|1q9q]], [[1q9r|1q9r]], [[1q9t|1q9t]], [[1q9v|1q9v]], [[1q9w|1q9w]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q9k OCA], [http://pdbe.org/1q9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q9k RCSB], [http://www.ebi.ac.uk/pdbsum/1q9k PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q9k OCA], [http://pdbe.org/1q9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q9k RCSB], [http://www.ebi.ac.uk/pdbsum/1q9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q9k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q9/1q9k_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q9/1q9k_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1q9k" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1q9k" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 11:01, 24 February 2018
S25-2 Fab Unliganded 1S25-2 Fab Unliganded 1
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedHigh-resolution structures reveal how a germline antibody can recognize a range of clinically relevant carbohydrate epitopes. The germline response to a carbohydrate immunogen can be critical to survivability, with selection for antibody gene segments that both confer protection against common pathogens and retain the flexibility to adapt to new disease organisms. We show here that antibody S25-2 binds several distinct inner-core epitopes of bacterial lipopolysaccharides (LPSs) by linking an inherited monosaccharide residue binding site with a subset of complementarity-determining regions (CDRs) of limited flexibility positioned to recognize the remainder of an array of different epitopes. This strategy allows germline antibodies to adapt to different epitopes while minimizing entropic penalties associated with the immobilization of labile CDRs upon binding of antigen, and provides insight into the link between the genetic origin of individual CDRs and their respective roles in antigen recognition. Germline antibody recognition of distinct carbohydrate epitopes.,Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:14625588[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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