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==X-ray crystal structure of aggregation-resistant protective antigen of Bacillus anthracis (mutant S559L T576E)== | ==X-ray crystal structure of aggregation-resistant protective antigen of Bacillus anthracis (mutant S559L T576E)== | ||
<StructureSection load='5fr3' size='340' side='right' caption='[[5fr3]], [[Resolution|resolution]] 1.94Å' scene=''> | <StructureSection load='5fr3' size='340' side='right' caption='[[5fr3]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Baets, G De]] | |||
[[Category: Beerten, J]] | [[Category: Beerten, J]] | ||
[[Category: Brams, M]] | [[Category: Brams, M]] | ||
[[Category: | [[Category: Durme, J van]] | ||
[[Category: Gallardo, R]] | [[Category: Gallardo, R]] | ||
[[Category: Ganesan, A]] | [[Category: Ganesan, A]] | ||
[[Category: Kant, R van der]] | |||
[[Category: Langenberg, T]] | [[Category: Langenberg, T]] | ||
[[Category: Ramakers, M]] | [[Category: Ramakers, M]] | ||
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[[Category: Schymkowitz, J]] | [[Category: Schymkowitz, J]] | ||
[[Category: Siekierska, A]] | [[Category: Siekierska, A]] | ||
[[Category: Smet, F De]] | |||
[[Category: Ulens, C]] | [[Category: Ulens, C]] | ||
[[Category: Wilkinson, H]] | [[Category: Wilkinson, H]] | ||
[[Category: Anthrax protective antigen]] | [[Category: Anthrax protective antigen]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 09:50, 2 March 2016
X-ray crystal structure of aggregation-resistant protective antigen of Bacillus anthracis (mutant S559L T576E)X-ray crystal structure of aggregation-resistant protective antigen of Bacillus anthracis (mutant S559L T576E)
Structural highlights
Function[PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax. |
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