5hkp: Difference between revisions

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-'''Unreleased structure'''
-The entry 5hkp is ON HOLD  until Paper Publication
+==Crystal structure of mouse Tankyrase/human TRF1 complex==
+<StructureSection load='5hkp' size='340' side='right' caption='[[5hkp]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors: Wang, Z., Li, B., Rao, Z., Xu, W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5hkp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HKP FirstGlance]. <br>
-Description: Crystal structure of mouse Tankyrase/human TRF1 complex
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hkp OCA], [http://pdbe.org/5hkp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hkp RCSB], [http://www.ebi.ac.uk/pdbsum/5hkp PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TNKS1_MOUSE TNKS1_MOUSE]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1 (By similarity). [[http://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN]] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Li, B]]
 [[Category: Rao, Z]]
 [[Category: Wang, Z]]
 [[Category: Xu, W]]
-[[Category: Li, B]]
+[[Category: Tankyrase]]
+[[Category: Telomere]]
+[[Category: Transferase - signaling protein complex]]
+[[Category: Trf1]]