Ferrochelatase: Difference between revisions
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<StructureSection load='1c1h' size='350' side='right' scene='' caption='Ferrochelatase with methylmesoporphyrin and Mg+2 ion (PDB code [[1c1h]])'> | <StructureSection load='1c1h' size='350' side='right' scene='' caption='Ferrochelatase with methylmesoporphyrin and Mg+2 ion (PDB code [[1c1h]])'> | ||
== Function == | |||
'''Ferrochelatase''' (FECH) catalyzes the last step in the formation of heme. FECH adds Fe+2 to protoporphyrin IX converting it to protoheme. The human FECH is a homodimer containing 2 similar domains and an iron-sulfur cluster. Defective FECH is the cause of porphyria. | '''Ferrochelatase''' (FECH) catalyzes the last step in the formation of heme. FECH adds Fe+2 to protoporphyrin IX converting it to protoheme. The human FECH is a homodimer containing 2 similar domains and an iron-sulfur cluster. | ||
== Disease == | |||
Defective FECH is the cause of porphyria<ref>PMID 11929052</ref>. | |||
'''Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of ''Bacillus subtilis'' ferrochelatase <ref>DOI 10.1007/s00775-010-0720-4</ref>''' | '''Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of ''Bacillus subtilis'' ferrochelatase <ref>DOI 10.1007/s00775-010-0720-4</ref>''' | ||
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**[[1c9e]] - BsFECH + N-methylmesoporphyrin + Cu + Mg<br /> | **[[1c9e]] - BsFECH + N-methylmesoporphyrin + Cu + Mg<br /> | ||
}} | }} | ||
== References == | |||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||