Estrogen-related receptor

Function Estrogen-related receptor (ERR) binds to estrogen response elements on DNA and modulates transcription in response to hormone. There are 3 classes of ERR : ERRα, ERRβ and ERRγ. Relevance ERR plays a role in energy homeostasis and cancer. ERRα and ERRγ are overexpressed in breast cancer and can serve as prognostic markers or therapeutic targets. Structural insights The chemotherapeutic drugs bisphenol and tamoxifen are nestled between 4 alpha helices in the ERR active site .

spinqualitylabelsall models Human estrogen-related receptor γ ligand-binding domain (cyan, grey, green, yellow, pink, purple) complex with nuclear receptor corepressor 2 peptide (dark red, orange) and 4-hydroxytamoxifen (PDB code 2gpv) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of estrogen-related receptor3D structures of estrogen-related receptor

Updated on 20-January-2016

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• ERR
  • 1xb7, 3d24 – hERR ligand-binding domain + peroxisome proliferator activated receptor coactivator 1 peptide – human
    2pjl - hERR ligand-binding domain (mutant) + inverse agonist
    
  • 3k6p - hERR ligand-binding domain + ligand
• ERRβ
  • 1lo1 – hERR DNA-binding domain + DNA - NMR
• ERRγ
  • 2gp7, 2zbs - hERR ligand-binding domain
    
  • 1kv6, 1tfc – hERR ligand-binding domain + steroid receptor coactivator 1 2nd NR-Box
    
  • 2gpo, 2gpp - hERR ligand-binding domain + nuclear receptor-interacting protein 1 peptide
    
  • 2ewp - hERR ligand-binding domain + tamoxifen analog
    
  • 2gpu, 2p7z - hERR ligand-binding domain + 4-hydroxytamoxifen
    
  • 2e2r, 2p7g - hERR ligand-binding domain + bisphenol A
    
  • 2zkc - hERR ligand-binding domain + bisphenol Z
    
  • 2zas - hERR ligand-binding domain + bisphenol A derivative
    
  • 2p7a - hERR ligand-binding domain + methyl phenol
    
  • 2gpv - hERR ligand-binding domain + nuclear receptor corepressor 2 peptide + 4-hydroxytamoxifen
    
  • 1s9p, 1s9q - mERR ligand-binding domain + diethylstilbesterol – mouse
    
  • 1vjb - mERR ligand-binding domain + 4-hydroxytamoxifen