1biw: Difference between revisions

Revision as of 11:34, 2 May 2008

DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS

OverviewOverview

A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety.

About this StructureAbout this Structure

1BIW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Design and synthesis of conformationally-constrained MMP inhibitors., Natchus MG, Cheng M, Wahl CT, Pikul S, Almstead NG, Bradley RS, Taiwo YO, Mieling GE, Dunaway CM, Snider CE, McIver JM, Barnett BL, McPhail SJ, Anastasio MB, De B, Bioorg Med Chem Lett. 1998 Aug 18;8(16):2077-80. PMID:9873489 Page seeded by OCA on Fri May 2 11:34:14 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1biw.jpg|left|200px]]
- {{Structure
+<!--
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+The line below this paragraph, containing "STRUCTURE_1biw", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=S80:N1-HYDROXY-2-(3-HYDROXY-PROPYL)-3-ISOBUTYL-N4-[1-(2-METHOXY-ETHYL)-2-OXO-AZEPAN-3-YL]-SUCCINAMIDE'>S80</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1biw|  PDB=1biw  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1biw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1biw OCA], [http://www.ebi.ac.uk/pdbsum/1biw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1biw RCSB]</span>
-}}
 '''DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS'''
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 [[Category: Taiwo, Y O.]]
 [[Category: Wahl, C T.]]
-[[Category: matrix metalloprotease]]
+[[Category: Matrix metalloprotease]]
-[[Category: osteoarthritis]]
+[[Category: Osteoarthritis]]
-[[Category: protein crystal structure]]
+[[Category: Protein crystal structure]]
-[[Category: stromelysin]]
+[[Category: Stromelysin]]
-[[Category: structure-based drug design]]
+[[Category: Structure-based drug design]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:34:14 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:01:57 2008''