Bungarotoxin: Difference between revisions

Revision as of 13:21, 3 April 2018

Bungarotoxins. α-Bungarotoxin (α-BGT), β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.

α-BGT binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in Alpha-bungarotoxin.
β-BGT binds to the presynaptic terminal causing release of acetylcholine.
γ-BGT inhibits the binding of quinoclidinyl bezilate to the M2 muscarinic acetylcholine receptor.
κ-BGT binds weakly to the nicotinic acetylcholine receptor.

For toxins in Proteopedia see Toxins.

in α-Bungarotoxin (PDB code 1hc9).^[1]

α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code 1hc9)

Drag the structure with the mouse to rotate

Updated on 03-April-2018

↑ Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 2001 Oct 25;32(2):265-75. PMID:11683996

@@ Line 30: / Line 30: @@
 **[[2qc1]] – α-BGT+mAChR α subunit <br />
-**[[4hqp]] - α−BGT+ AChR α7 subunit<br />
+**[[5hbt]] - α-BGT+ hAChR α1 subunit + antibody<br />
-**[[4uy2]] - α−BGT+ AChR α9 subunit<br />
+**[[5hbv]] - α-BGT+ mAChR α1 subunit + antibody<br />
+**[[4hqp]] - α−BGT+ hAChR α7 subunit<br />
+**[[4uy2]] - α−BGT+ hAChR α9 subunit<br />
 }}
 == References ==