1bg1: Difference between revisions

Revision as of 11:27, 2 May 2008

TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX

OverviewOverview

STAT proteins are a family of eukaryotic transcription factors that mediate the response to a large number of cytokines and growth factors. Upon activation by cell-surface receptors or their associated kinases, STAT proteins dimerize, translocate to the nucleus and bind to specific promoter sequences on their target genes. Here we report the first crystal structure of a STAT protein bound to its DNA recognition site at 2.25 A resolution. The structure provides insight into the various steps by which STAT proteins deliver a response signal directly from the cell membrane to their target genes in the nucleus.

About this StructureAbout this Structure

1BG1 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Three-dimensional structure of the Stat3beta homodimer bound to DNA., Becker S, Groner B, Muller CW, Nature. 1998 Jul 9;394(6689):145-51. PMID:9671298 Page seeded by OCA on Fri May 2 11:27:52 2008

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OCA

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 [[Image:1bg1.gif|left|200px]]
- {{Structure
+<!--
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-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bg1 OCA], [http://www.ebi.ac.uk/pdbsum/1bg1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bg1 RCSB]</span>
-}}
 '''TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX'''
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 [[Category: Groner, B.]]
 [[Category: Muller, C W.]]
-[[Category: complex (transcription factor/dna)]]
+[[Category: Cytokine activation]]
-[[Category: cytokine activation]]
+[[Category: Protein-dna complex]]
-[[Category: protein-dna complex]]
+[[Category: Transcription factor]]
-[[Category: transcription factor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:27:52 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:00:09 2008''