2mxc: Difference between revisions

Revision as of 22:30, 13 May 2016

Solution structure of the full length sorting nexin 3Solution structure of the full length sorting nexin 3

Structural highlights

2mxc is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Disease

[SNX3_HUMAN] MMEP syndrome. The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving SNX3 has been found in patients with syndromic microphthalmia. Translocation t(6;13)(q21;q12).

Function

[SNX3_HUMAN] Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation.^[1] ^[2]

References

↑ Xu Y, Hortsman H, Seet L, Wong SH, Hong W. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol. 2001 Jul;3(7):658-66. PMID:11433298 doi:http://dx.doi.org/10.1038/35083051
↑ Pons V, Luyet PP, Morel E, Abrami L, van der Goot FG, Parton RG, Gruenberg J. Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol. 2008 Sep 2;6(9):e214. doi: 10.1371/journal.pbio.0060214. PMID:18767904 doi:http://dx.doi.org/10.1371/journal.pbio.0060214

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OCA

[1] Xu Y, Hortsman H, Seet L, Wong SH, Hong W. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol. 2001 Jul;3(7):658-66. PMID:11433298 doi:http://dx.doi.org/10.1038/35083051

[2] Pons V, Luyet PP, Morel E, Abrami L, van der Goot FG, Parton RG, Gruenberg J. Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol. 2008 Sep 2;6(9):e214. doi: 10.1371/journal.pbio.0060214. PMID:18767904 doi:http://dx.doi.org/10.1371/journal.pbio.0060214

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 2mxc is ON HOLD  until Apr 30 2017
+==Solution structure of the full length sorting nexin 3==
+<StructureSection load='2mxc' size='340' side='right' caption='[[2mxc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-Authors: Lenoir, M.M.L., Rajesh, S.S.R., Gruenberg, J.J.G., Overduin, M.M.O., Kaur, J.J.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2mxc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MXC FirstGlance]. <br>
-Description: Solution structure of the full length sorting nexin 3
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mxc OCA], [http://pdbe.org/2mxc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mxc RCSB], [http://www.ebi.ac.uk/pdbsum/2mxc PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Overduin, M.M.O]]
+== Disease ==
-[[Category: Rajesh, S.S.R]]
+[[http://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN]] MMEP syndrome. The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving SNX3 has been found in patients with syndromic microphthalmia. Translocation t(6;13)(q21;q12).
-[[Category: Gruenberg, J.J.G]]
+== Function ==
-[[Category: Kaur, J.J.K]]
+[[http://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN]] Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation.<ref>PMID:11433298</ref> <ref>PMID:18767904</ref>
-[[Category: Lenoir, M.M.L]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gruenberg, J J.G]]
+[[Category: Kaur, J J.K]]
+[[Category: Lenoir, M M.L]]
+[[Category: Overduin, M M.O]]
+[[Category: Rajesh, S S.R]]
+[[Category: Endosome]]
+[[Category: Membrane]]
+[[Category: Pi3p]]
+[[Category: Protein transport]]
+[[Category: Snx3]]

2mxc: Difference between revisions

Revision as of 22:30, 13 May 2016

Solution structure of the full length sorting nexin 3Solution structure of the full length sorting nexin 3

Structural highlights

Disease

Function

References

Contents

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2mxc: Difference between revisions

Revision as of 22:30, 13 May 2016

Solution structure of the full length sorting nexin 3Solution structure of the full length sorting nexin 3

Structural highlights

Disease

Function

References

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