ABC transporter: Difference between revisions
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To achieve export, ABC transporters require a minimum of four domains. Two transmembrane domains (TMDs) form the ligand binding sites and provide specificity, and two NBDs bind and hydrolyze ATP to drive the trans-location of the bound ligand. The NBDs, but not the TMDs, are homologous throughout the family and have several characteristic motifs including the Walker A (GxxGxGKST) and B (ILLDEAT) motifs common to many nucleotide binding proteins and others like the ABC signature, stacking aromatic D, H, and Q loops, which are unique to the family<ref name="FourDomainsABCT"/>. | To achieve export, ABC transporters require a minimum of four domains. Two transmembrane domains (TMDs) form the ligand binding sites and provide specificity, and two NBDs bind and hydrolyze ATP to drive the trans-location of the bound ligand. The NBDs, but not the TMDs, are homologous throughout the family and have several characteristic motifs including the Walker A (GxxGxGKST) and B (ILLDEAT) motifs common to many nucleotide binding proteins and others like the ABC signature, stacking aromatic D, H, and Q loops, which are unique to the family<ref name="FourDomainsABCT"/>. | ||
*<scene name='42/429005/Cv/4'>Active site</scene> of Arginine ABC transporter complex with arginine (PDB code [[3tql]]). | |||
== Disease == | == Disease == | ||