1bdw: Difference between revisions

Revision as of 11:23, 2 May 2008

GRAMICIDIN D FROM BACILLUS BREVIS (ACTIVE FORM)

OverviewOverview

The linear pentadecapeptide antibiotic, gramicidin D, is a naturally occurring product of Bacillus brevis known to form ion channels in synthetic and natural membranes. The x-ray crystal structures of the right-handed double-stranded double-helical dimers (DSDH) reported here agree with 15N-NMR and CD data on the functional gramicidin D channel in lipid bilayers. These structures demonstrate single-file ion transfer through the channels. The results also indicate that previous crystal structure reports of a left-handed double-stranded double-helical dimer in complex with Cs+ and K+ salts may be in error and that our evidence points to the DSDH as the major conformer responsible for ion transport in membranes.

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

The conducting form of gramicidin A is a right-handed double-stranded double helix., Burkhart BM, Li N, Langs DA, Pangborn WA, Duax WL, Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12950-5. PMID:9789021 Page seeded by OCA on Fri May 2 11:23:18 2008

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OCA

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 [[Image:1bdw.gif|left|200px]]
- {{Structure
+<!--
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+The line below this paragraph, containing "STRUCTURE_1bdw", creates the "Structure Box" on the page.
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-|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=FOR:FORMYL+GROUP'>FOR</scene>
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-|GENE=
+-->
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-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bdw OCA], [http://www.ebi.ac.uk/pdbsum/1bdw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bdw RCSB]</span>
-}}
 '''GRAMICIDIN D FROM BACILLUS BREVIS (ACTIVE FORM)'''
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 ==About this Structure==
-BDW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BDW OCA].
+Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BDW OCA].
 ==Reference==
 The conducting form of gramicidin A is a right-handed double-stranded double helix., Burkhart BM, Li N, Langs DA, Pangborn WA, Duax WL, Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12950-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9789021 9789021]
-[[Category: Brevibacillus brevis]]
-[[Category: Protein complex]]
 [[Category: Burkhart, B M.]]
 [[Category: Duax, W L.]]
 [[Category: Pangborn, W A.]]
-[[Category: peptide antibiotic]]
+[[Category: Peptide antibiotic]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:23:18 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:59:00 2008''