DNA polymerase: Difference between revisions
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'''Klenow fragment''' is a large Dpo fragment produced upon cleavage of Dpo by [[Subtilisin|subtilisin]].<br /> | '''Klenow fragment''' is a large Dpo fragment produced upon cleavage of Dpo by [[Subtilisin|subtilisin]].<br /> | ||
In the ''E. coli'', the EcDpo III subunits β, γ, δ, δ' are named '''clamp loader'''. This complex assembles the β subunit sliding clamp unto the DNA.<br /> | In the ''E. coli'', the EcDpo III subunits β, γ, δ, δ' are named '''clamp loader'''. This complex assembles the β subunit sliding clamp unto the DNA.<br /> | ||
'''Rev1''' is a '''Dpo''' involved in replication over DNA lesions. <br /> | |||
'''Terminal deoxynucleotidyl transferase (TdT)''' is a family X Dpo expressed in immature lymphoid cells. TdT adds nucleotides to exons during antibody gene recombination.<br /> | Prokaryotic DNA polymerases:<br /> | ||
* '''DNA polymerase I''': involved in excision repair. Major polymerase in E. coli.<br /> | |||
* '''DNA polymerase II''': active in replication forks.<br /> | |||
* '''DNA polymerase III''': involved in DNA replication.<br /> | |||
* '''DNA polymerase IV''': involved in non-targeted mutagenesis.<br /> | |||
* '''DNA polymerase V''': involved in translesion synthesis.<br /> | |||
Eukaryotic DNA polymerases:<br /> | |||
* '''Pol α,β,γ,δ,ε,ζ,η,ι,κ'''<br /> | |||
* '''Rev1''' is a '''Dpo''' involved in replication over DNA lesions. <br /> | |||
* '''Terminal deoxynucleotidyl transferase (TdT)''' is a family X Dpo expressed in immature lymphoid cells. TdT adds nucleotides to exons during antibody gene recombination.<br /> | |||
For more details see<br /> | For more details see<br /> | ||
* [[DNA Polymerase I]]<br /> | * [[DNA Polymerase I]]<br /> | ||