1b7t: Difference between revisions

Revision as of 11:10, 2 May 2008

MYOSIN DIGESTED BY PAPAIN

OverviewOverview

The crystal structure of a proteolytic subfragment from scallop striated muscle myosin, complexed with MgADP, has been solved at 2.5 A resolution and reveals an unusual conformation of the myosin head. The converter and the lever arm are in very different positions from those in either the pre-power stroke or near-rigor state structures; moreover, in contrast to these structures, the SH1 helix is seen to be unwound. Here we compare the overall organization of the myosin head in these three states and show how the conformation of three flexible "joints" produces rearrangements of the four major subdomains in the myosin head with different bound nucleotides. We believe that this novel structure represents one of the prehydrolysis ("ATP") states of the contractile cycle in which the myosin heads stay detached from actin.

About this StructureAbout this Structure

1B7T is a Protein complex structure of sequences from Argopecten irradians. The following page contains interesting information on the relation of 1B7T with [Myosin]. Full crystallographic information is available from OCA.

ReferenceReference

Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head., Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C, Cell. 1999 May 14;97(4):459-70. PMID:10338210 Page seeded by OCA on Fri May 2 11:10:58 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1b7t.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1b7t |SIZE=350|CAPTION= <scene name='initialview01'>1b7t</scene>, resolution 2.5&Aring;
+The line below this paragraph, containing "STRUCTURE_1b7t", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1b7t|  PDB=1b7t  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b7t OCA], [http://www.ebi.ac.uk/pdbsum/1b7t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b7t RCSB]</span>
-}}
 '''MYOSIN DIGESTED BY PAPAIN'''
@@ Line 31: / Line 28: @@
 [[Category: Kalabokis, V.]]
 [[Category: Szent-Gyorgyi, A G.]]
-[[Category: myosin motor]]
+[[Category: Myosin motor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:10:58 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:55:25 2008''