1b72: Difference between revisions

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[[Image:1b72.gif|left|200px]]
[[Image:1b72.gif|left|200px]]


{{Structure
<!--
|PDB= 1b72 |SIZE=350|CAPTION= <scene name='initialview01'>1b72</scene>, resolution 2.35&Aring;
The line below this paragraph, containing "STRUCTURE_1b72", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=
or leave the SCENE parameter empty for the default display.
|GENE= HOXB-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PBX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
-->
|DOMAIN=
{{STRUCTURE_1b72| PDB=1b72  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b72 OCA], [http://www.ebi.ac.uk/pdbsum/1b72 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b72 RCSB]</span>
}}


'''PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX'''
'''PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX'''
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[[Category: Piper, D E.]]
[[Category: Piper, D E.]]
[[Category: Wolberger, C.]]
[[Category: Wolberger, C.]]
[[Category: complex]]
[[Category: Complex]]
[[Category: dna]]
[[Category: Dna]]
[[Category: dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: homeodomain]]
[[Category: Homeodomain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:09:09 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:54:57 2008''

Revision as of 11:09, 2 May 2008

File:1b72.gif

Template:STRUCTURE 1b72

PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX


OverviewOverview

Hox homeodomain proteins are developmental regulators that determine body plan in a variety of organisms. A majority of the vertebrate Hox proteins bind DNA as heterodimers with the Pbx1 homeodomain protein. We report here the 2.35 A structure of a ternary complex containing a human HoxB1-Pbx1 heterodimer bound to DNA. Heterodimer contacts are mediated by the hexapeptide of HoxB1, which binds in a pocket in the Pbx1 protein formed in part by a three-amino acid insertion in the Pbx1 homeodomain. The Pbx1 DNA-binding domain is larger than the canonical homeodomain, containing an additional alpha helix that appears to contribute to binding of the HoxB1 hexapeptide and to stable binding of Pbx1 to DNA. The structure suggests a model for modulation of Hox DNA binding activity by Pbx1 and related proteins.

DiseaseDisease

Known disease associated with this structure: Leukemia, acute pre-B-cell OMIM:[176310]

About this StructureAbout this Structure

1B72 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation., Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C, Cell. 1999 Feb 19;96(4):587-97. PMID:10052460 Page seeded by OCA on Fri May 2 11:09:09 2008

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