5fbx: Difference between revisions

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-'''Unreleased structure'''
+==Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor==
+<StructureSection load='5fbx' size='340' side='right' caption='[[5fbx]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-The entry 5fbx is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fbx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FBX FirstGlance]. <br>
-Authors: Tallant, C., Clark, P.G.K., Siejka, P., Fedorov, O., Nowak, R., Srikannathasan, V., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Dixon, D., Knapp, S.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5W4:(3~{S})-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-3-PHENYL-3~{H}-ISOINDOL-1-ONE'>5W4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbx OCA], [http://pdbe.org/5fbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fbx RCSB], [http://www.ebi.ac.uk/pdbsum/5fbx PDBsum]</span></td></tr>
-Description: Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
+</table>
-[[Category: Unreleased Structures]]
+== Disease ==
-[[Category: Nowak, R]]
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Brennan, P E]]
+[[Category: Clark, P G.K]]
+[[Category: Delft, F von]]
+[[Category: Dixon, D]]
+[[Category: Edwards, A M]]
 [[Category: Fedorov, O]]
+[[Category: Knapp, S]]
 [[Category: Muller, S]]
+[[Category: Nowak, R]]
 [[Category: Siejka, P]]
-[[Category: Knapp, S]]
+[[Category: Srikannathasan, V]]
-[[Category: Clark, P.G.K]]
-[[Category: Bountra, C]]
-[[Category: Arrowsmith, C.H]]
-[[Category: Dixon, D]]
-[[Category: Von Delft, F]]
-[[Category: Edwards, A.M]]
 [[Category: Tallant, C]]
-[[Category: Srikannathasan, V]]
+[[Category: Baf180]]
+[[Category: Brg1-associated factor 180]]
+[[Category: Chromatin remodeling]]
+[[Category: Transcription]]