1b0u: Difference between revisions

Revision as of 10:55, 2 May 2008

ATP-BINDING SUBUNIT OF THE HISTIDINE PERMEASE FROM SALMONELLA TYPHIMURIUM

OverviewOverview

ABC transporters (also known as traffic ATPases) form a large family of proteins responsible for the translocation of a variety of compounds across membranes of both prokaryotes and eukaryotes. The recently completed Escherichia coli genome sequence revealed that the largest family of paralogous E. coli proteins is composed of ABC transporters. Many eukaryotic proteins of medical significance belong to this family, such as the cystic fibrosis transmembrane conductance regulator (CFTR), the P-glycoprotein (or multidrug-resistance protein) and the heterodimeric transporter associated with antigen processing (Tap1-Tap2). Here we report the crystal structure at 1.5 A resolution of HisP, the ATP-binding subunit of the histidine permease, which is an ABC transporter from Salmonella typhimurium. We correlate the details of this structure with the biochemical, genetic and biophysical properties of the wild-type and several mutant HisP proteins. The structure provides a basis for understanding properties of ABC transporters and of defective CFTR proteins.

About this StructureAbout this Structure

1B0U is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the ATP-binding subunit of an ABC transporter., Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF, Kim SH, Nature. 1998 Dec 17;396(6712):703-7. PMID:9872322 Page seeded by OCA on Fri May 2 10:55:57 2008

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OCA

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 [[Image:1b0u.jpg|left|200px]]
- {{Structure
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-}}
 '''ATP-BINDING SUBUNIT OF THE HISTIDINE PERMEASE FROM SALMONELLA TYPHIMURIUM'''
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 [[Category: Nikaido, K.]]
 [[Category: Wang, I X.]]
-[[Category: abc transporter]]
+[[Category: Abc transporter]]
-[[Category: histidine permease]]
+[[Category: Histidine permease]]
-[[Category: transport protein]]
+[[Category: Transport protein]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:55:57 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:51:25 2008''