5f36: Difference between revisions

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-'''Unreleased structure'''
-The entry 5f36 is ON HOLD  until Dec 02 2017
+==Crystal structure of the bromodomain of human ATAD2 in complex with Compound A12==
+<StructureSection load='5f36' size='340' side='right' caption='[[5f36]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors: Dong, J., Caflisch, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5f36]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F36 FirstGlance]. <br>
-Description: Crystal structure of the bromodomain of human ATAD2 in complex with Compound A12
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UE:[(2~{R})-1-[(4-ETHANOYL-1,3-THIAZOL-2-YL)AMINO]-1-OXIDANYLIDENE-PROPAN-2-YL]AZANIUM'>5UE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f36 OCA], [http://pdbe.org/5f36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f36 RCSB], [http://www.ebi.ac.uk/pdbsum/5f36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f36 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Adenosinetriphosphatase]]
+[[Category: Caflisch, A]]
 [[Category: Dong, J]]
-[[Category: Caflisch, A]]
+[[Category: Hydrolase inhibitor complex]]
+[[Category: Transferase]]