5e24: Difference between revisions

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'''Unreleased structure'''


The entry 5e24 is ON HOLD  until Paper Publication
==Structure of the Su(H)-Hairless-DNA Repressor Complex==
 
<StructureSection load='5e24' size='340' side='right' caption='[[5e24]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
Authors: Kovall, R.A., Yuan, Z.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5e24]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E24 FirstGlance]. <br>
Description: Structure of the Su(H)-Hairless-DNA Repressor Complex
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MTT:MALTOTETRAOSE'>MTT</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e24 OCA], [http://pdbe.org/5e24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e24 RCSB], [http://www.ebi.ac.uk/pdbsum/5e24 PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity). [[http://www.uniprot.org/uniprot/SUH_DROME SUH_DROME]] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Required for neurogenesis in imaginal disks. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Required for transcription of Sim. Also functions independently of Notch pathway, in the development of the bristle sensory organ precursor cell.<ref>PMID:10673509</ref> <ref>PMID:12642500</ref> <ref>PMID:7813798</ref>  [[http://www.uniprot.org/uniprot/HLES_DROME HLES_DROME]] Is a potent antagonist of neurogenic gene activity during sensory organ development. The expression of distinct cell fates by the trichogen (shaft) / tormogen (socket) sister cell pair depends on the level of H activity. A certain threshold level of H activity is required, below which both sister cells adopt the tormogen fate.<ref>PMID:1419850</ref> <ref>PMID:1516831</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Kovall, R A]]
[[Category: Yuan, Z]]
[[Category: Yuan, Z]]
[[Category: Kovall, R.A]]
[[Category: Csl]]
[[Category: Hairless]]
[[Category: Notch signaling]]
[[Category: Suppressor of hairless]]
[[Category: Transport-dna binding-dna complex]]

Revision as of 01:24, 21 June 2016

Structure of the Su(H)-Hairless-DNA Repressor ComplexStructure of the Su(H)-Hairless-DNA Repressor Complex

Structural highlights

5e24 is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity). [SUH_DROME] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Required for neurogenesis in imaginal disks. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Required for transcription of Sim. Also functions independently of Notch pathway, in the development of the bristle sensory organ precursor cell.[1] [2] [3] [HLES_DROME] Is a potent antagonist of neurogenic gene activity during sensory organ development. The expression of distinct cell fates by the trichogen (shaft) / tormogen (socket) sister cell pair depends on the level of H activity. A certain threshold level of H activity is required, below which both sister cells adopt the tormogen fate.[4] [5]

References

  1. ↑ Morel V, Schweisguth F. Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev. 2000 Feb 1;14(3):377-88. PMID:10673509
  2. ↑ Koelzer S, Klein T. A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila. Development. 2003 May;130(9):1973-88. PMID:12642500
  3. ↑ Schweisguth F, Nero P, Posakony JW. The sequence similarity of the Drosophila suppressor of hairless protein to the integrase domain has no functional significance in vivo. Dev Biol. 1994 Dec;166(2):812-4. PMID:7813798 doi:http://dx.doi.org/10.1006/dbio.1994.1359
  4. ↑ Maier D, Stumm G, Kuhn K, Preiss A. Hairless, a Drosophila gene involved in neural development, encodes a novel, serine rich protein. Mech Dev. 1992 Aug;38(2):143-56. PMID:1419850
  5. ↑ Bang AG, Posakony JW. The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development. Genes Dev. 1992 Sep;6(9):1752-69. PMID:1516831

5e24, resolution 2.14Å

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