1awc: Difference between revisions

Revision as of 10:46, 2 May 2008

MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA

OverviewOverview

GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif.

About this StructureAbout this Structure

1AWC is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA., Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C, Science. 1998 Feb 13;279(5353):1037-41. PMID:9461436 Page seeded by OCA on Fri May 2 10:46:29 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1awc.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1awc |SIZE=350|CAPTION= <scene name='initialview01'>1awc</scene>, resolution 2.150&Aring;
+The line below this paragraph, containing "STRUCTURE_1awc", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=BRU:5-BROMO-2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=CBR:5-BROMO-2&#39;-DEOXY-CYTIDINE-5&#39;-MONOPHOSPHATE'>CBR</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= GABP ALPHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), GABP BETA 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+-->
-|DOMAIN=
+{{STRUCTURE_1awc|  PDB=1awc  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1awc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1awc OCA], [http://www.ebi.ac.uk/pdbsum/1awc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1awc RCSB]</span>
-}}
 '''MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA'''
@@ Line 27: / Line 24: @@
 [[Category: Batchelor, A H.]]
 [[Category: Wolberger, C.]]
-[[Category: ankyrin repeat]]
+[[Category: Ankyrin repeat]]
-[[Category: complex (transcription regulation/dna)]]
+[[Category: Dna-binding]]
-[[Category: dna-binding]]
+[[Category: Ets domain]]
-[[Category: ets domain]]
+[[Category: Nuclear protein]]
-[[Category: nuclear protein]]
+[[Category: Transcription factor]]
-[[Category: transcription factor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:46:29 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:48:47 2008''